NEK2 - NIMA related kinase 2 Gene

中文名称：NIMA 相关激酶 2

种属: Homo sapiens

同用名: NLK1; RP67; NEK2A; HsPK21; PPP1R111

基因 ID: 4751 | 基因类型: protein coding

关于 NEK2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,658,256-211,675,621 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues.

功能概要

该基因编码参与有丝分裂调节的丝氨酸/苏氨酸蛋白激酶。这种蛋白质定位于中心体，在 G1 期检测不到，但在整个 S 期逐渐积累，在 G2 后期达到最大水平。编码具有不同 C 末端的不同亚型的选择性剪接转录物变体已被注意到该基因。[RefSeq 提供，2011 年 2 月]

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

NEK2 基因产物(3)

mRNA	Protein	Name
NM_001204182.2	NP_001191111.1	serine/threonine-protein kinase Nek2 isoform 3
NM_001204183.2	NP_001191112.1	serine/threonine-protein kinase Nek2 isoform 2
NM_002497.4	NP_002488.1	serine/threonine-protein kinase Nek2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9647649	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	10880350	GOA
enables protein kinase activity	IMP IMP: 通过突变表型推断	24554434	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	10880350	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in centrosome separation	IDA IDA: 通过直接分析推断	18086858	GOA
involved in chromosome segregation	IDA IDA: 通过直接分析推断	14978040	GOA
involved in negative regulation of centriole-centriole cohesion	IMP IMP: 通过突变表型推断	24554434	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: 通过突变表型推断	21531765	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	17626005	GOA
involved in protein autophosphorylation	IMP IMP: 通过突变表型推断	10880350	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	21076410	GOA
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	24554434	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: 通过突变表型推断	18297113	GOA
involved in regulation of mitotic centrosome separation	IMP IMP: 通过突变表型推断	26220856	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA
colocalizes with kinetochore	IDA IDA: 通过直接分析推断	17621308	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	14978040	GOA
part of protein-containing complex	IMP IMP: 通过突变表型推断	10880350	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEK2 蛋白结构

Pkinase

0
100
200
300
400
445 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase Nek2

NIMA (never in mitosis gene a)-related kinase 2

NEK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NEK2	P51955	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	23288039
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	IF	26290419
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	Protein Kinase Assay	26290419
Intra	NEK2	P51955	MCC	Homo sapiens	P23508	Y2H	21900206
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Far-WB	24116158
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Y2H	21382349
Intra	NEK2	P51955	NEK11	Homo sapiens	Q8NG66	Pull Down	15161910
Intra	NEK2	P51955	CDC27	Homo sapiens	P30260	Anti Bait CoIP	16648845
Cross	NEK2	P51955	MGC80529	Crosspus laevis	Q6GQ04	Anti Bait CoIP	16648845

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinitis Pigmentosa 67

RP67	Retinitis Pigmentosa, Type 67

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-120356A	T-1101 tosylate	Inhibitor	99.05%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-16660	INH1	Inhibitor	99.85%	否
HY-117154	INH154		99.89%	否
HY-101029	MBM-55	Inhibitor	99.94%	否
HY-116423	JH295		98.99%	否
HY-100541	INH6	Inhibitor	99.90%	否
HY-101030A	MBM-17S	Inhibitor	/	否
HY-B0790	TAI-1	Inhibitor	98.02%	否
HY-137046	Nek2-IN-4		/	否
HY-116423A	JH295 hydrate		≥99.0%	否
HY-101030	MBM-17	Inhibitor	/	否
HY-101029A	MBM-55S	Inhibitor	/	否
HY-120356	T-1101	Inhibitor	/	否
HY-150046	Nek2-IN-6		/	否
HY-153749	Nek2/Hec1-IN-2		≥98.0%	否
HY-156437	NBI-961	Inhibitor	99.73%	否
HY-120330	Nek2-IN-5		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NEK2	VGNC	VGNC:75308
Mus musculus	NEK2	MGD	MGI:109359
Canis familiaris	NEK2	VGNC	VGNC:43731
Bos taurus	NEK2	VGNC	VGNC:31993
Felis catus	NEK2	VGNC	VGNC:68456
Rattus norvegicus	NEK2	RGD	RGD:619792
Others	NEK2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NEK2 - NIMA related kinase 2 Gene

关于 NEK2

功能概要

NEK2 基因产物(3)

NEK2 蛋白结构

NEK2 蛋白互作信息

关联疾病

直系同源

热门区域

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NEK2 - NIMA related kinase 2 Gene

关于 NEK2

功能概要

NEK2 基因产物(3)

NEK2 蛋白结构

NEK2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z