2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis NEKs
  4. T-1101

T-1101 (TAI-95) 是口服有效的抑制剂，可以抑制调节有丝分裂的高表达癌蛋白 1 (Hec1)。T-1101 可阻断 Hec1 和 NEK2 之间的相互作用，在人肝癌细胞中表现出细胞毒性，GI50 为 15-70 nM。T-1101 可诱导 Huh-7 细胞凋亡 (apoptosis)。T-1101 在小鼠模型中表现出抗肿瘤活性。

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T-1101 Chemical Structure

T-1101 Chemical Structure

CAS No. : 1438638-83-5

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T-1101 的其他形式现货产品:

Customer Review

Other Forms of T-1101:

T-1101 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 NEKs 亚型特异性产品:

查看所有亚型
NEK1 NEK2 NEK6 NEK7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models[1].

IC50 & Target

NEK2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COLO 205 GI50
29.1 nM
Compound: 9j
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
HeLa IC50
21.1 nM
Compound: 9j
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
Huh-7 GI50
34.98 nM
Compound: 9j
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
Huh-7 GI50
59.9 nM
Compound: 9j
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
K562 IC50
18 nM
Compound: 9j
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
MDA-MB-231 IC50
14.8 nM
Compound: 9j
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
MDA-MB-468 IC50
21.5 nM
Compound: 9j
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
U2OS GI50
83.2 nM
Compound: 9j
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
U-937 GI50
12.4 nM
Compound: 9j
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
[PMID: 32113126]
分子量

493.60

Formula

C24H23N5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

T-1101 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-11011438638-83-5TAI-95T1101T 1101TAI95TAI 95ApoptosisNEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed Kinasesprimary liver cancerHCChepatoblastomaHuh-7HepG2WI-38HUVECRPTECHep3BJHHSNUSCID mouseorally activeInhibitorinhibitorinhibit

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