KIF24 - kinesin family member 24 Gene

中文名称：驱动蛋白家族成员 24

种属: Homo sapiens

同用名: C9orf48; bA571F15.4

基因 ID: 347240 | 基因类型: protein coding

关于 KIF24

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,252,380-34,333,671 (from NCBI)

This gene has 3 transcripts (splice variants), 168 orthologues and 41 paralogues. Broad expression in testis (RPKM 7.5), bone marrow (RPKM 4.2) and 25 other tissues.

功能概要

该基因编码基于微管的马达蛋白驱动蛋白超家族的成员，这些马达蛋白参与膜细胞器、蛋白质复合物和 mRNA 的细胞内转运。它们还在有丝分裂、形态发生和信号转导中发挥关键作用。编码的蛋白质包含一个 N 末端无菌 alpha 基序 (SAM) 结构域和一个 ATP 结合驱动蛋白运动结构域。它结合中心粒卷曲螺旋蛋白 110 和中心体蛋白 97，定位于母中心粒，通过控制微管聚合来调节纤毛发生。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the Kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding Kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]

KIF24 基因产物(1)

mRNA	Protein	Name
NM_194313.4	NP_919289.2	kinesin-like protein KIF24

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26290419	GOA
enables microtubule motor activity	IDA IDA: 通过直接分析推断	21620453	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21620453	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cilium assembly	IMP IMP: 通过突变表型推断	21620453	GOA
involved in microtubule depolymerization	IDA IDA: 通过直接分析推断	21620453	GOA
involved in negative regulation of cilium assembly	IMP IMP: 通过突变表型推断	30375385	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centriole	IDA IDA: 通过直接分析推断	21620453	GOA
located in centrosome	IDA IDA: 通过直接分析推断	30375385	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	24421332	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF24 蛋白结构

SAM_1

Kinesin

0
300
600
900
1200
1368 a.a.

蛋白主名

其他名称

kinesin-like protein KIF24

KIF24 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	21620453
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	24421332
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	21620453
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	26496610
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	24421332
种属内	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	33961781
种属内	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Bait CoIP	21620453
种属内	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Bait CoIP	24421332
种属内	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	24421332
种属内	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	33961781
种属内	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	21620453
种属内	KIF24	Q5T7B8	NEK2	Homo sapiens	P51955	Anti Bait CoIP	26290419
种属内	KIF24	Q5T7B8	NEK2	Homo sapiens	P51955	Anti Tag CoIP	26290419

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 3	Saldino-Noonan Syndrome
SRTD3	Atd3
Srps1	Srps3
Verma-Naumoff Syndrome	Srps2b
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type	Short Rib-Polydactyly Syndrome, Type I
Polydactyly With Neonatal Chondrodystrophy, Type I	Polydactyly With Neonatal Chondrodystrophy, Type Iii
Short Rib-Polydactyly Syndrome, Type Iib	Short Rib-Polydactyly Syndrome Type 3
Polydactyly With Neonatal Chondrodystrophy Type Iii	Short Rib-Polydactyly Syndrome Type Iii
Short Rib-Polydactyly Syndrome Type 1	Short Rib-Polydactyly Syndrome, Saldino-Noonan Type
Majewski Syndrome	Short Rib-Polydactyly Syndrome, Type Iii
Type I Short Rib Polydactyly Syndrome	Srps Type 3
Short Rib Polydactyly Syndrome Verma Naumoff Type	Verma Naumoff Syndrome
Polydactyly With Neonatal Chondrodystrophy Type 1	Srps Type 1
Short Rib-Polydactyly Syndrome Saldino-Noonan Type	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 3
Polydactyly With Neonatal Chondrodystrophy Type I	Short Rib-Polydactyly Syndrome Type I
Short Rib-Polydactyly Syndrome Type Iib	Srps Type Iib
Srps Type Iii

Orofaciodigital Syndrome I

OFD1	Orofaciodigital Syndrome 1
Oral-Facial-Digital Syndrome, Type I	Oral-Facial-Digital Syndrome 1
Ofds I	Papillon-Leage And Psaume Syndrome
Papillon-Leage-Psaume Syndrome	Oral-Facial-Digital Syndrome Type 1
Orofaciodigital Syndrome Type 1	Orofaciodigital Syndromes
Orofaciodigital Syndrome Type I	Oral-Facial-Digital Syndrome Type I
Ofd Syndrome 1	Ofds 1
Oral Facial Digital Syndrome 1	Oral Facial Digital Syndrome Type 1
Papillon-League-Psaume Syndrome	Ofdi
Ofdsi	Orofaciodigital Syndrome, Type I

Joubert Syndrome 23

JBTS23

Joubert Syndrome, Type 23

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Joubert Syndrome 5

JBTS5

Joubert Syndrome, Type 5

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Meckel Syndrome, Type 1

Meckel-Gruber Syndrome	Meckel Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07278	KIF24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KIF24	VGNC	VGNC:42399
Bos taurus	KIF24	VGNC	VGNC:30597
Macaca mulatta	KIF24	VGNC	VGNC:73864
Felis catus	KIF24	VGNC	VGNC:63114
Mus musculus	KIF24	MGD	MGI:1918345
Rattus norvegicus	KIF24	RGD	RGD:1307723

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KIF24 - kinesin family member 24 Gene

关于 KIF24

功能概要

KIF24 基因产物(1)

KIF24 蛋白结构

KIF24 蛋白互作信息

关联疾病

直系同源

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KIF24 - kinesin family member 24 Gene

关于 KIF24

功能概要

KIF24 基因产物(1)

KIF24 蛋白结构

KIF24 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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