2. Cell Cycle/DNA Damage
  3. NEKs
  4. Nek2-IN-6

Nek2-IN-6 (Compound 28e) 是一种有效的 NIMA 相关激酶 2 (Nek2) 抑制剂。

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Nek2-IN-6 Chemical Structure

Nek2-IN-6 Chemical Structure

CAS No. : 2410376-96-2

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Nek2-IN-6 相关抗体

Top Publications Citing Use of Products

查看 NEKs 亚型特异性产品:

查看所有亚型
NEK1 NEK2 NEK6 NEK7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor[1].

IC50 & Target

NEK2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Bel-7402 IC50
10.44 μM
Compound: 28e
Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Bel-7402 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 32992252]
HCT-116 IC50
0.48 μM
Compound: 28e
Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 32992252]
Hep 3B2 IC50
1.25 μM
Compound: 28e
Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 32992252]
MGC-803 IC50
0.038 μM
Compound: 28e
Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antitumor activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 32992252]
体外研究
(In Vitro)

Nek2-IN-6 (Compound 28e) (0-30 μM; 72 h) inhibits tumor cells proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nek2-IN-6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MGC-803, Hep-3B, BEL-7402, HCT-116
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Inhibited cell proliferation with IC50s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.
分子量

666.71

Formula

C33H33F3N6O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nek2-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nek2-IN-62410376-96-2NEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesNek2NIMAnever in mitosis related kinase 2MGC-803Hep-3BBEL-7402HCT-116Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150046
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