2. Gene
  3. NEK11 - NIMA related kinase 11 Gene

NEK11 - NIMA related kinase 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NIMA 相关激酶 11

种属: Homo sapiens

基因 ID: 79858 | 基因类型: protein coding

关于 NEK11

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,026,877-131,350,465 (from NCBI)

This gene has 17 transcripts (splice variants), 169 orthologues and 8 paralogues. Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.7) and 22 other tissues.

功能概要

该基因编码永不在有丝分裂基因 A 激酶家族的成员。编码的蛋白质定位于核仁，并可能在 S 期检查点与 NEK2A 一起发挥作用。编码的蛋白质似乎在 DNA 复制和对基因毒性应激的反应中发挥作用。已经描述了选择性剪接的转录变体。[RefSeq 提供，2009 年 3 月]

This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

NEK11 基因产物(33)

mRNA Protein Name
NM_001146003.2 NP_001139475.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001321220.2 NP_001308149.1 serine/threonine-protein kinase Nek11 isoform 1
NM_001321221.2 NP_001308150.1 serine/threonine-protein kinase Nek11 isoform 4
NM_001321222.2 NP_001308151.1 serine/threonine-protein kinase Nek11 isoform 5
NM_001321223.1 NP_001308152.1 serine/threonine-protein kinase Nek11 isoform 6
NM_001321224.2 NP_001308153.1 serine/threonine-protein kinase Nek11 isoform 7
NM_001353022.2 NP_001339951.1 serine/threonine-protein kinase Nek11 isoform 4
NM_001353023.2 NP_001339952.1 serine/threonine-protein kinase Nek11 isoform 1
NM_001353024.2 NP_001339953.1 serine/threonine-protein kinase Nek11 isoform 8
NM_001353025.2 NP_001339954.1 serine/threonine-protein kinase Nek11 isoform 8
NM_001353026.2 NP_001339955.1 serine/threonine-protein kinase Nek11 isoform 9
NM_001353027.2 NP_001339956.1 serine/threonine-protein kinase Nek11 isoform 10
NM_001353028.2 NP_001339957.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001353029.2 NP_001339958.1 serine/threonine-protein kinase Nek11 isoform 3
NM_001353030.2 NP_001339959.1 serine/threonine-protein kinase Nek11 isoform 11
NM_001353031.2 NP_001339960.1 serine/threonine-protein kinase Nek11 isoform 11
NM_001353032.2 NP_001339961.1 serine/threonine-protein kinase Nek11 isoform 5
NM_001353033.2 NP_001339962.1 serine/threonine-protein kinase Nek11 isoform 12
NM_001353034.2 NP_001339963.1 serine/threonine-protein kinase Nek11 isoform 12
NM_001353036.2 NP_001339965.1 serine/threonine-protein kinase Nek11 isoform 13
NM_001353037.2 NP_001339966.1 serine/threonine-protein kinase Nek11 isoform 14
NM_001353038.2 NP_001339967.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353039.2 NP_001339968.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353040.2 NP_001339969.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353041.2 NP_001339970.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353042.2 NP_001339971.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353043.2 NP_001339972.1 serine/threonine-protein kinase Nek11 isoform 15
NM_001353044.2 NP_001339973.1 serine/threonine-protein kinase Nek11 isoform 16
NM_001353045.2 NP_001339974.1 serine/threonine-protein kinase Nek11 isoform 16
NM_001353046.2 NP_001339975.1 serine/threonine-protein kinase Nek11 isoform 7
NM_001353048.2 NP_001339977.1 serine/threonine-protein kinase Nek11 isoform 17
NM_024800.5 NP_079076.3 serine/threonine-protein kinase Nek11 isoform 1
NM_145910.4 NP_665917.1 serine/threonine-protein kinase Nek11 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
15161910 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161910 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15161910 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
15161910 GOA
involved in mitotic intra-S DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
15161910 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15161910 GOA
involved in regulation of mitotic cell cycle phase transition IMP
IMP: 通过突变表型推断
12154088 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
15161910 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEK11 蛋白结构

Pkinase

Pkinase: Protein kinase domain (29 - 287)

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  • 645 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Nek11

NIMA (never in mitosis gene a)- related kinase 11

NEK11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NEK11 Q8NG66 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra NEK11 Q8NG66 NEK2 Homo sapiens P51955
Anti Bait CoIP
15161910
Intra NEK11 Q8NG66 NEK2 Homo sapiens P51955
IF
15161910
Intra NEK11 Q8NG66 NEK2 Homo sapiens P51955
Protein Kinase Assay
15161910
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly

Majewski Syndrome

SRTD6

Srps2a

Short Rib-Polydactyly Syndrome, Majewski Type

Polydactyly With Neonatal Chondrodystrophy, Type Ii

Short Rib-Polydactyly Syndrome Type Iia

Short Rib-Polydactyly Syndrome Type 2

Short Rib-Polydactyly Syndrome Type Ii

Short Rib-Polydactyly Syndrome, Type Ii

Srps, Type Ii

Short Rib-Polydactyly Syndrome, Type Iia

Polydactyly With Neonatal Chondrodystrophy Type 2

Srps Type 2

Short Rib-Polydactyly Syndrome Majewski Type

Polydactyly With Neonatal Chondrodystrophy Type Ii

Short Rib-Polydactyly Syndrome 2a

Srps Type Ii
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09192 NEK11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NEK11 MGD MGI:2442276
Felis catus NEK11 VGNC VGNC:102788
Bos taurus NEK11 VGNC VGNC:53591
Rattus norvegicus NEK11 RGD RGD:1308801
Canis familiaris NEK11 VGNC VGNC:52894
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