2. Cell Cycle/DNA Damage
  3. NEKs
  4. Nek2-IN-5

Nek2-IN-5 (compound 6) 是一种有效且不可逆的 Nek2 ((从未在有丝分裂基因a中)相关激酶2) 抑制剂。Nek2-IN-5 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Nek2-IN-5 Chemical Structure

Nek2-IN-5 Chemical Structure

CAS No. : 1507367-00-1

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥5121
3 - 4 周
5 mg   询价  
10 mg   询价  

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Nek2-IN-5 相关抗体

Top Publications Citing Use of Products

查看 NEKs 亚型特异性产品:

查看所有亚型
NEK1 NEK2 NEK6 NEK7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior[1]. Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

NEK2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 GI50
18.1 μM
Compound: 66
Growth inhibition against human HCT116 cells incubated for 72 hrs
Growth inhibition against human HCT116 cells incubated for 72 hrs
[PMID: 33479670]
HeLa GI50
32.2 μM
Compound: 66
Growth inhibition of human HeLa cells incubated for 72 hrs
Growth inhibition of human HeLa cells incubated for 72 hrs
[PMID: 33479670]
HeLa GI50
47.1 μM
Compound: 66
Growth inhibition of human HeLa cells measured after 92 hrs by CellTiter Blue assay
Growth inhibition of human HeLa cells measured after 92 hrs by CellTiter Blue assay
[PMID: 33479670]
MCF7 GI50
6.6 μM
Compound: 66
Growth inhibition against human MCF-7 cells incubated for 72 hrs
Growth inhibition against human MCF-7 cells incubated for 72 hrs
[PMID: 33479670]
Rec1 GI50
1.6 μM
Compound: 66
Growth inhibition against human Rec-1 cells incubated for 72 hrs
Growth inhibition against human Rec-1 cells incubated for 72 hrs
[PMID: 33479670]
SK-BR-3 GI50
2.2 μM
Compound: 66
Growth inhibition against human SKBR3 cells incubated for 72 hrs
Growth inhibition against human SKBR3 cells incubated for 72 hrs
[PMID: 33479670]
T47D GI50
3.6 μM
Compound: 66
Growth inhibition against human T47D cells incubated for 72 hrs
Growth inhibition against human T47D cells incubated for 72 hrs
[PMID: 33479670]
U2OS GI50
71 μM
Compound: 66
Growth inhibition of human U2OS cells measured after 92 hrs by CellTiter Blue assay
Growth inhibition of human U2OS cells measured after 92 hrs by CellTiter Blue assay
[PMID: 33479670]
分子量

292.30

Formula

C15H12N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nek2-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nek2-IN-51507367-00-1NEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed Kinases6-ethynylpurinecancercysteineInhibitorinhibitorinhibit

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目录号：
HY-120330
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