Dvl2 - dishevelled segment polarity protein 2 Gene

种属: Mus musculus

基因 ID: 13543 | 基因类型: protein coding

关于 Dvl2

功能概要

Enables several functions, including Enzyme binding activity; Frizzled binding activity; and identical protein binding activity. Involved in several processes, including outflow tract morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of protein tyrosine kinase activity; and segment specification. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and retina. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dvl2 基因产物(1)

mRNA	Protein	Name
NM_007888.4	NP_031914.3	segment polarity protein dishevelled homolog DVL-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables frizzled binding	IPI IPI: 通过物理相互作用推断	20802536	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17529994	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12805222	MGI
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	15579909	MGI
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	17244647	MGI
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	23109420	MGI
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	23109420	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Wnt signaling pathway	IMP IMP: 通过突变表型推断	25190059	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: 通过遗传相互作用推断	16116426	MGI
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	8887313	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	17606995	MGI
involved in canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	10409711	MGI
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	18093802	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: 通过遗传相互作用推断	16116426	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IGI IGI: 通过遗传相互作用推断	16571627	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IMP IMP: 通过突变表型推断	16571627	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: 通过遗传相互作用推断	16116426	MGI
acts upstream of or within heart development	IMP IMP: 通过突变表型推断	12421720	MGI
involved in heart looping	IGI IGI: 通过遗传相互作用推断	22841628	MGI
acts upstream of or within heart morphogenesis	IGI IGI: 通过遗传相互作用推断	19008950	MGI
acts upstream of or within neural tube closure	IMP IMP: 通过突变表型推断	12421720	MGI
involved in outflow tract morphogenesis	IGI IGI: 通过遗传相互作用推断	22841628	MGI
involved in outflow tract morphogenesis	IMP IMP: 通过突变表型推断	12464179	MGI
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	23109420	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: 通过直接分析推断	10829020	MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity	IGI IGI: 通过遗传相互作用推断	19920076	MGI
acts upstream of or within protein localization	IDA IDA: 通过直接分析推断	17606995	MGI
acts upstream of or within segment specification	IMP IMP: 通过突变表型推断	12421720	MGI
involved in segmentation	IGI IGI: 通过遗传相互作用推断	8887313	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical part of cell	IDA IDA: 通过直接分析推断	19300477	MGI
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	17005174	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	17244647	MGI
located in cytosol	IDA IDA: 通过直接分析推断	21189423	MGI
located in lateral plasma membrane	IDA IDA: 通过直接分析推断	23533177	MGI
located in nucleus	IMP IMP: 通过突变表型推断	19465938	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	16116426	MGI
located in plasma membrane	IGI IGI: 通过遗传相互作用推断	17606995	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

segment polarity protein dishevelled homolog DVL-2

DSH homolog 2	dishevelled 2, dsh homolog
dishevelled-2

Dvl2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	GMS	21189423
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	Solution Sedimentation	21189423
Intra	Dvl2	Q60838	DIXDC1	Homo sapiens	Q155Q3	Pull Down	21189423
Intra	Dvl2	Q60838	Dvl3	Mus musculus	Q61062	Confocal	21092292
Cross	Dvl2	Q60838	DAAM1	Homo sapiens	Q9Y4D1-1	Anti Tag CoIP	18162551
Cross	Dvl2	Q60838	DAAM1	Homo sapiens	Q9Y4D1-1	Pull Down	18162551
Intra	Dvl2	Q60838	Vangl1	Mus musculus	Q80Z96	Anti Bait CoIP	15456783
Intra	Dvl2	Q60838	Vangl2	Mus musculus	Q91ZD4	Y2H	15456783
Intra	Dvl2	Q60838	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	21718540
Intra	Dvl2	Q60838	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	19701191
Cross	Dvl2	Q60838	WWOX	Homo sapiens	Q9NZC7	Anti Tag CoIP	25678599
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Anti Bait CoIP	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Peptide Array	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Pull Down	22609948
Intra	Dvl2	Q60838	PLK1	Homo sapiens	P53350	Anti Tag CoIP	22609948
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	GMS	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Solution Sedimentation	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Pull Down	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	GMS	21189423
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	TEM	17529994
Intra	Dvl2	Q60838	Dvl2	Mus musculus	Q60838	Solution Sedimentation	21189423
Cross	Dvl2	Q60838	CSNK1E	Homo sapiens	P49674	Pull Down	22609948
Cross	Dvl2	Q60838	CSNK1D	Homo sapiens	P48730	Protein Kinase Assay	22609948
Cross	Dvl2	Q60838	Ap2m1	Rattus norvegicus	P84092	Pull Down	20947020
Cross	Dvl2	Q60838	Ap2m1	Rattus norvegicus	P84092	GMS	20947020

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100853	IWP-O1	Inhibitor	99.81%	否
HY-RS04077	DVL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Dvl2	NCBI	NCBI:1856

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