2. Gene
  3. Ap2m1 - adaptor related protein complex 2 subunit mu 1 Gene

Ap2m1 - adaptor related protein complex 2 subunit mu 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: mu2; Ap50; Clapm1

基因 ID: 116563 | 基因类型: protein coding

关于 Ap2m1

功能概要

Enables low-density lipoprotein particle receptor binding activity and signal sequence binding activity. Involved in positive regulation of endocytosis; protein-containing complex assembly; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap2m1 基因产物(1)

mRNA Protein Name
NM_053837.2 NP_446289.1 AP-2 complex subunit mu
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables low-density lipoprotein particle receptor binding IDA
IDA: 通过直接分析推断
12121421 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9162036 RGD
enables signal sequence binding IDA
IDA: 通过直接分析推断
12121421 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of receptor internalization IMP
IMP: 通过突变表型推断
12105201 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
19762466 RGD
involved in postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
17289840 RGD
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
17289840 RGD
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
17289840 RGD
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
2870069 RGD
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
19321783 RGD
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
19321783 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of AP-2 adaptor complex IDA
IDA: 通过直接分析推断
12086608 RGD
is active in extrinsic component of presynaptic endocytic zone membrane IDA
IDA: 通过直接分析推断
8682861 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
17289840 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17289840 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17289840 RGD
is active in synaptic vesicle EXP
EXP: 通过实验结果推断
33376223 RGD
is active in synaptic vesicle IDA
IDA: 通过直接分析推断
33376223 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

AP-2 complex subunit mu

AP-2 mu chain

adapter-related protein complex 2 mu subunit

adapter-related protein complex 2 subunit mu

adaptor protein complex AP-2 subunit mu

adaptor-related protein complex 2 subunit mu

adaptor-related protein complex 2, mu 1 subunit

clathrin ass

Ap2m1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Ap2m1 P84092 Ttgn1 Rattus norvegicus P19814
Y2H
9341158
Intra Ap2m1 P84092 Ttgn1 Rattus norvegicus P19814
Fluorescence Spectr
9162036
Cross Ap2m1 P84092 ITGA2 Homo sapiens P17301
Pull Down
26779610
Cross Ap2m1 P84092 ITGA2 Homo sapiens P17301
ITC
26779610
Cross Ap2m1 P84092 ITGA4 Homo sapiens P13612
X-Ray Diffraction
26779610
Cross Ap2m1 P84092 ITGA4 Homo sapiens P13612
ITC
26779610
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-161261 SARS-CoV-2-IN-81 Inhibitor / 否
HY-RS00787 AP2M1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ap2m1 NCBI NCBI:1173
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