1. Gene
  2. ITGA2 - integrin subunit alpha 2 Gene

ITGA2 - integrin subunit alpha 2 Gene

中文名称:整合素亚基 alpha 2

种属: Homo sapiens

同用名: BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2

基因 ID: 3673 | 基因类型: protein coding

关于 ITGA2

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,989,352-53,094,779 (from NCBI)

This gene has 6 transcripts (splice variants), 240 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 8.4), adrenal (RPKM 7.9) and 21 other tissues.

功能概要

该基因编码胶原蛋白和相关蛋白质的跨膜受体的α亚基。编码的蛋白质与 β 亚基形成异二聚体,并介导血小板和其他细胞类型与细胞外基质的粘附。编码蛋白的丢失与 9 型血小板出血性疾病有关。针对这种蛋白的抗体存在于多种免疫疾病中,包括新生儿同种免疫性血小板减少症。该基因位于相关的α亚基基因附近。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 8 月]

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and Other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

ITGA2 基因产物(1)

mRNA Protein Name
NM_002203.4 NP_002194.2 integrin alpha-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IMP
IMP: 通过突变表型推断
11518510 GOA
enables collagen binding involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
24823363 GOA
enables collagen receptor activity IMP
IMP: 通过突变表型推断
11518510 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7639691 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
25336636 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
11518510 GOA
involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
11518510 GOA
involved in cell-substrate adhesion IMP
IMP: 通过突变表型推断
19933311 GOA
involved in collagen-activated signaling pathway IMP
IMP: 通过突变表型推断
11518510 GOA
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
24823363 GOA
involved in mesodermal cell differentiation IEP
IEP: 通过表达模式推断
23154389 GOA
involved in substrate-dependent cell migration IMP
IMP: 通过突变表型推断
11518510 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19933311 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
11518510 GOA
part of integrin alpha2-beta1 complex IDA
IDA: 通过直接分析推断
24823363 GOA
part of integrin alpha2-beta1 complex IPI
IPI: 通过物理相互作用推断
14681217 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21310825 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ITGA2 蛋白结构

VWA

VWA: von Willebrand factor type A domain (174 - 351)

FG-GAP

FG-GAP: FG-GAP repeat (554 - 589)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (649 - 1048)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1181 a.a.
蛋白主名 其他名称

integrin alpha-2

CD49 antigen-like family member B

ITGA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ITGA2 P17301 KDR Homo sapiens P35968 21596751
种属间
ITGA2 P17301 Rab21 Mus musculus P35282 16754960
种属间
ITGA2 P17301 Rab21 Mus musculus P35282
Y2H
16754960
种属间
ITGA2 P17301 Rab21 Mus musculus P35282 16754960
种属间
ITGA2 P17301 Rab21 Mus musculus P35282 16754960
种属内
ITGA2 P17301 SHARPIN Homo sapiens Q9H0F6 21947080
种属内
ITGA2 P17301 SHARPIN Homo sapiens Q9H0F6
FPS
21947080
种属内
ITGA2 P17301 SHARPIN Homo sapiens Q9H0F6 21947080
种属内
ITGA2 P17301 ITGB1 Homo sapiens P05556 14681217
种属内
ITGA2 P17301 ITGB1 Homo sapiens P05556 10397731
种属内
ITGA2 P17301 ITGB1 Homo sapiens P05556 21947080
种属间: 跨种属相互作用 种属内: 同种属相互作用

ITGA2 抗体

目录号 产品名 应用 反应物种
HY-P83362 Integrin alpha 2 Antibody (YA3107) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Fetal And Neonatal Alloimmune Thrombocytopenia

Nait

Neonatal Alloimmune Thrombocytopenia

Fnait

Bleeding Disorder, Platelet-Type, 9

Platelet-Type Bleeding Disorder 9

Glycoprotein Ia Deficiency

BDPLT9

Gp Ia Deficiency

Collagen Platelet Receptor Deficiency

Bleeding Diathesis Due To Integrin Alpha2-Beta1 Deficiency

Bleeding Disorder, Platelet Type 9

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Septic Arthritis

Infectious Arthritis

Arthritis, Infectious

Arthritis Septic

Arthritis, Bacterial

Bleeding Disorder, Platelet-Type, 11

BDPLT11

Glycoprotein Vi Deficiency

Gp Vi Deficiency

Platelet-Type Bleeding Disorder 11

Bleeding Diathesis Due To A Collagen Receptor Defect

Bleeding Diathesis Due To Glycoprotein Vi Deficiency

Platelet-Type Bleeding Disorder-11

Bleeding Disorder, Platelet Type 11

Hemorrhage

Gingival Overgrowth

Gingival Enlargement

Gingival Hyperplasia

Gingival Bulge

Gingival Enlargement Nos

Gingival Hypertrophy

Gum Hypertrophy

Hyperplasia Gum

Gingival Thickening

Hyperplasia Of Gingiva

Hypertrophy Of Gingiva

Hypertrophy Of Mucous Membrane Of Gums

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia

Thrombasthenia Of Glanzmann And Naegeli

Glanzmann'S Thrombasthenia

Bdplt2

Platelet Glycoprotein Iib-Iiia Deficiency

Deficiency Of Platelet Fibrinogen Receptor

GT1

Gt

Platelet Fibrinogen Receptor Deficiency

Glycoprotein Complex Iib-Iiia Deficiency

Deficiency Of Glycoprotein Complex Iib-Iiia

Glycoprotein Iib/Iiia Defect

Glanzmann Thrombasthenia, Type A

Thrombasthenia

Bleeding Disorder, Platelet-Type, 2

Gp Iib-Iiia Complex Deficiency

Deficiency Of Gp Iib-Iiia Complex

Platelet-Type Bleeding Disorder 2

Thrombocytasthenia

Deficiency Of Gp 2b 3a Complex

Diacyclothrombopathia 2b 3a

Glanzmann Thrombasthenia Type A

Platelet Fibrinogen Receptor, Deficiency Of

Platelet Glycoprotein 2b 3a Deficiency

Glanzmann Disease

Glanzmann-Naegeli Disorder

Hereditary Hemorrhagic Thrombasthenia

Hereditary Thrombasthenia

Bleeding Disorder Platelet-Type 2

Bernard-Soulier Syndrome

Giant Platelet Syndrome

BSS

Von Willebrand Factor Receptor Deficiency

Bdplt1

Platelet Glycoprotein Ib Deficiency

Bernard-Soulier Syndrome, Type A1

Bernard-Soulier Syndrome, Type B

Bernard Soulier Syndrome

Deficiency Of Platelet Glycoprotein 1b

Hemorrhagiparous Thrombocytic Dystrophy

Bernard-Soulier Syndrome Type C

Bleeding Disorder, Platelet-Type, 1

Glycoprotein Ib, Platelet, Deficiency Of

Giant Platelet Disorder, Isolated

Giant Platelet Disease

Macrothrombocytopenia, Familial Bernard-Soulier Type

Bernard-Soulier Syndrome, Type C

Bernard - Soulier Thrombopathy

Hemorrhagic Dystrophic Thrombocytopenia

Thrombopathy, Bernard-Soulier

Platelet Glycoprotein 1b, Deficiency Of

Hemorrhagioparous Thrombocytic Dystrophy

Bernard-Soulier Syndrome Type A1

Bernard-Soulier Syndrome Type B

Bleeding Disorder Platelet-Type 1

Gpd

Macrothrombocytopenia, Familial, Bernard-Soulier Type

Thrombosis

Thrombosis Of Blood Vessel

Thrombasthenia
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

Smed-Sl

Smed-Sl/Ac

Smed Short Limb-Abnormal Calcification Type

Smed Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

Smed, Type Ii

Smed Type 2

Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

Smed, Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

Smed, Short Limb-Abnormal Calcification Type

Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

SEMD-SL

Smed Type Ii

Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type

Rhabdomyosarcoma
Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Arteriosclerosis

Arteriosclerotic Vascular Disease

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Diabetes Mellitus

Diabetes

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus ITGA2 VGNC VGNC:30313
Canis familiaris ITGA2 VGNC VGNC:42123
Felis catus ITGA2 VGNC VGNC:67839
Rattus norvegicus ITGA2 RGD RGD:621632
Macaca mulatta ITGA2 VGNC VGNC:73775
Mus musculus ITGA2 MGD MGI:96600
Macaca fascicularis ITGA2 NCBI NCBI:102133302
Others ITGA2 NCBI