2. Gene
  3. Dact1 - dishevelled-binding antagonist of beta-catenin 1 Gene

Dact1 - dishevelled-binding antagonist of beta-catenin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Frd1; FRODO; MDpr1; MTNG3; DAPPER; Frodo1; THYEX3; DAPPER1; 4921528D17Rik

基因 ID: 59036 | 基因类型: protein coding

关于 Dact1

功能概要

Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in embryonic hindgut morphogenesis and regulation of signal transduction. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dact1 基因产物(2)

mRNA Protein Name
NM_001190466.1 NP_001177395.1 dapper homolog 1 isoform 1
NM_021532.4 NP_067507.2 dapper homolog 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables delta-catenin binding IDA
IDA: 通过直接分析推断
21718540 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11970895 MGI
enables protein kinase A binding IDA
IDA: 通过直接分析推断
21718540 MGI
enables protein kinase C binding IDA
IDA: 通过直接分析推断
21718540 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20145239 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: 通过遗传相互作用推断
20335472 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
20335472 MGI
involved in embryonic hindgut morphogenesis IMP
IMP: 通过突变表型推断
20145239 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: 通过突变表型推断
19701191 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: 通过突变表型推断
19701191 MGI
involved in negative regulation of JNK cascade IDA
IDA: 通过直接分析推断
17197390 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
17197390 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
19073771 MGI
acts upstream of or within positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
19073771 MGI
acts upstream of or within regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: 通过遗传相互作用推断
19701191 MGI
involved in regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
20145239 MGI
NOT involved in regulation of nodal signaling pathway IDA
IDA: 通过直接分析推断
17197390 MGI
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
20335472 MGI
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
20335472 MGI
acts upstream of or within synapse organization IMP
IMP: 通过突变表型推断
20335472 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20335472 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
20335472 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
20335472 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
20335472 MGI
is active in postsynapse IEP
IEP: 通过表达模式推断
20335472 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dapper homolog 1

dapper 1

dapper antagonist of catenin 1

dapper homolog 1, antagonist of beta-catenin

frodo homolog

thymus expressed gene 3

thymus-expressed novel gene 3 protein

Dact1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Pull Down
14636582
种属内
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Anti Tag CoIP
21718540
种属内
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Fluorescence Spectr
14636582
种属内
Dact1 Q8R4A3 Vangl2 Mus musculus Q91ZD4
Anti Tag CoIP
21718540
种属内
Dact1 Q8R4A3 Vangl2 Mus musculus Q91ZD4
Pull Down
19701191
种属内
Dact1 Q8R4A3 Dact3 Mus musculus Q0PHV7
Anti Tag CoIP
21718540
种属内
Dact1 Q8R4A3 Dvl2 Mus musculus Q60838
Anti Tag CoIP
19701191
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03515 DACT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dact1 NCBI NCBI:51339
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