Vangl2 - VANGL planar cell polarity 2 Gene

种属: Mus musculus

同用名: Lp; Lpp1; Ltap; stbm; Lootl; ska17; Vang1l2; loop-tail; strabismus; ska; C530001F03Rik

基因 ID: 93840 | 基因类型: protein coding

关于 Vangl2

功能概要

Involved in axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Acts upstream of or within several processes, including animal organ development; morphogenesis of an epithelium; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vangl2 基因产物(1)

mRNA	Protein	Name
NM_033509.4	NP_277044.1	vang-like protein 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15195140	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within Rho protein signal transduction	IMP IMP: 通过突变表型推断	20223754	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: 通过遗传相互作用推断	17433286	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: 通过突变表型推断	16116426	MGI
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: 通过突变表型推断	21106844	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: 通过突变表型推断	18849982	MGI
acts upstream of or within apical protein localization	IMP IMP: 通过突变表型推断	16495441	MGI
involved in cell migration involved in kidney development	IMP IMP: 通过突变表型推断	20534871	MGI
acts upstream of or within cochlea development	IGI IGI: 通过遗传相互作用推断	18066062	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: 通过遗传相互作用推断	17433286	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: 通过突变表型推断	16116426	MGI
acts upstream of or within convergent extension involved in axis elongation	IMP IMP: 通过突变表型推断	17229766	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IGI IGI: 通过遗传相互作用推断	16571627	MGI
acts upstream of or within convergent extension involved in neural plate elongation	IMP IMP: 通过突变表型推断	16571627	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: 通过遗传相互作用推断	17433286	MGI
acts upstream of or within digestive tract morphogenesis	IGI IGI: 通过遗传相互作用推断	19300477	MGI
involved in dopaminergic neuron axon guidance	IMP IMP: 通过突变表型推断	21106844	MGI
acts upstream of or within establishment of body hair planar orientation	IMP IMP: 通过突变表型推断	18849982	MGI
acts upstream of or within establishment of planar polarity	IGI IGI: 通过遗传相互作用推断	20643356	MGI
involved in establishment of planar polarity	IMP IMP: 通过突变表型推断	12724779	MGI
acts upstream of or within establishment of planar polarity involved in neural tube closure	IMP IMP: 通过突变表型推断	18606138	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: 通过突变表型推断	17376975	MGI
acts upstream of or within glomerulus development	IMP IMP: 通过突变表型推断	20843830	MGI
acts upstream of or within hair follicle development	IMP IMP: 通过突变表型推断	18849982	MGI
involved in heart looping	IMP IMP: 通过突变表型推断	11440971	MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process	IMP IMP: 通过突变表型推断	23760952	MGI
acts upstream of or within inner ear receptor cell development	IGI IGI: 通过遗传相互作用推断	20940229	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IGI IGI: 通过遗传相互作用推断	18066062	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: 通过突变表型推断	18606138	MGI
acts upstream of or within kidney morphogenesis	IMP IMP: 通过突变表型推断	20843830	MGI
acts upstream of or within lateral sprouting involved in lung morphogenesis	IMP IMP: 通过突变表型推断	20223754	MGI
acts upstream of or within membranous septum morphogenesis	IGI IGI: 通过遗传相互作用推断	20940229	MGI
acts upstream of or within muscular septum morphogenesis	IGI IGI: 通过遗传相互作用推断	20940229	MGI
acts upstream of or within neural tube closure	IGI IGI: 通过遗传相互作用推断	14512015	MGI
acts upstream of or within neural tube closure	IMP IMP: 通过突变表型推断	11709546	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	19497282	MGI
acts upstream of or within non-motile cilium assembly	IGI IGI: 通过遗传相互作用推断	16170314	MGI
acts upstream of or within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: 通过突变表型推断	20223754	MGI
acts upstream of or within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: 通过突变表型推断	20223754	MGI
acts upstream of or within positive regulation of JUN kinase activity	IGI IGI: 通过遗传相互作用推断	15195140	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: 通过突变表型推断	21761479	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: 通过突变表型推断	24302887	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	20223754	MGI
acts upstream of or within regulation of establishment of planar polarity	IGI IGI: 通过遗传相互作用推断	19300477	MGI
involved in regulation of synapse pruning	IDA IDA: 通过直接分析推断	34407949	MGI
involved in regulation of synapse pruning	IMP IMP: 通过突变表型推断	34407949	MGI
involved in serotonergic neuron axon guidance	IMP IMP: 通过突变表型推断	21106844	MGI
acts upstream of or within somatic stem cell division	IMP IMP: 通过突变表型推断	19497282	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	19497282	MGI
acts upstream of or within wound healing	IGI IGI: 通过遗传相互作用推断	20643356	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in COPII-coated ER to Golgi transport vesicle	IDA IDA: 通过直接分析推断	19966784	MGI
located in apical cytoplasm	IDA IDA: 通过直接分析推断	25333478	MGI
located in apical plasma membrane	IDA IDA: 通过直接分析推断	16687519	MGI
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	20534871	MGI
located in cell periphery	IDA IDA: 通过直接分析推断	20215345	MGI
located in cell pole	IDA IDA: 通过直接分析推断	19497282	MGI
located in cell-cell junction	IDA IDA: 通过直接分析推断	15195140	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	34407949	MGI
located in lateral plasma membrane	IDA IDA: 通过直接分析推断	17433286	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	16962386	MGI
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	34407949	MGI
located in stress fiber	IDA IDA: 通过直接分析推断	24302887	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

vang-like protein 2

loop tail associated protein	loop-tail protein 1
van Gogh-like protein 2	vang-like 2 (van gogh, Drosophila)

Vangl2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Vangl2	Q91ZD4	Dvl1	Mus musculus	P51141	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dvl3	Mus musculus	Q61062	Y2H	15456783
Intra	Vangl2	Q91ZD4	Dvl3	Mus musculus	Q61062	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	19701191
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Pull Down	15456783
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Anti Bait CoIP	15456783
Intra	Vangl2	Q91ZD4	Dvl2	Mus musculus	Q60838	Anti Tag CoIP	19701191
Cross	Vangl2	Q91ZD4	Dlg4	Rattus norvegicus	P31016	Pull Down	23567299
Cross	Vangl2	Q91ZD4	Dlg4	Rattus norvegicus	P31016	Anti Tag CoIP	23567299

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15601	VANGL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Vangl2	NCBI	NCBI:57216

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