1. Gene
  2. Dvl3 - dishevelled segment polarity protein 3 Gene

Dvl3 - dishevelled segment polarity protein 3 Gene

种属: Mus musculus

同用名: b2b2866Clo

基因 ID: 13544 | 基因类型: protein coding

关于 Dvl3

功能概要

Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway via JNK cascade. Acts upstream of or within cochlea morphogenesis; outflow tract septum morphogenesis; and planar cell polarity pathway involved in neural tube closure. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dvl3 基因产物(2)

mRNA Protein Name
NM_001347176.1 NP_001334105.1 segment polarity protein dishevelled homolog DVL-3 isoform 2
NM_007889.3 NP_031915.2 segment polarity protein dishevelled homolog DVL-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11274398 MGI
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
23109420 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: 通过遗传相互作用推断
19008950 MGI
involved in canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
18093802 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: 通过遗传相互作用推断
19008950 MGI
acts upstream of or within heart morphogenesis IGI
IGI: 通过遗传相互作用推断
19008950 MGI
involved in non-canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
11274398 MGI
involved in non-canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
23109420 MGI
acts upstream of or within outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
19008950 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Wnt signalosome IDA
IDA: 通过直接分析推断
22899650 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17005174 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16501258 MGI
is active in synapse IDA
IDA: 通过直接分析推断
16501258 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

segment polarity protein dishevelled homolog DVL-3

dishevelled 3, dsh homolog

Dvl3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dvl3 Q61062 Vangl1 Mus musculus Q80Z96
Y2H
15456783
种属内
Dvl3 Q61062 Dvl2 Mus musculus Q60838 21092292
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dvl3 NCBI NCBI:1857