RNF125 - ring finger protein 125 Gene

中文名称：无名指蛋白 125

种属: Homo sapiens

同用名: TNORS; TRAC1; TRAC-1

基因 ID: 54941 | 基因类型: protein coding

关于 RNF125

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,018,825-32,088,144 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues.

功能概要

该基因编码一种新型 E3 泛素连接酶，该酶在 N 末端包含一个环指结构域，在 C 末端包含三个锌结合基序和一个泛素相互作用基序。作为豆蔻酰化的结果，该蛋白质与膜结合并且主要定位于细胞内膜系统。所编码的蛋白质可以作为 T 细胞受体信号通路中的正调节剂发挥作用。[RefSeq 提供，2012 年 3 月]

This gene encodes a novel E3 ubiquitin Ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

RNF125 基因产物(1)

mRNA	Protein	Name
NM_017831.4	NP_060301.2	E3 ubiquitin-protein ligase RNF125

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables p53 binding	IPI IPI: 通过物理相互作用推断	25591766	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17460044	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: 通过物理相互作用推断	27411375	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	17460044	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	27411375	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of RIG-I signaling pathway	IDA IDA: 通过直接分析推断	17460044	GOA
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	17460044	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	27411375	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	17460044	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	17990982	GOA
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: 通过直接分析推断	26471729	GOA
located in intracellular membrane-bounded organelle	IDA IDA: 通过直接分析推断	17990982	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF125 蛋白结构

zf-RING_2

zf-Di19

0
100
200
232 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase RNF125

T-cell RING activation protein 1

RNF125 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RNF125	Q96EQ8	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786-1	Anti Bait CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786-1	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	UBE2E2	Homo sapiens	Q96LR5	Y2H	17460044
Intra	RNF125	Q96EQ8	UBE2E2	Homo sapiens	Q96LR5	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	VCP	Homo sapiens	P55072	Pull Down	26471729
Intra	RNF125	Q96EQ8	VCP	Homo sapiens	P55072	Anti Bait CoIP	26471729
Intra	RNF125	Q96EQ8	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	17460044
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786	Anti Bait CoIP	26471729
Intra	RNF125	Q96EQ8	RIGI	Homo sapiens	O95786	Pull Down	26471729

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Tenorio Syndrome

TNORS

Overgrowth, Macrocephaly, And Intellectual Disability Syndrome

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D	Hmn Iid
Dhmn2d	Distal Hereditary Motor Neuronopathy Type 2d
Distal Hereditary Motor Neuropathy Type Iid	Neuronopathy, Distal Hereditary Motor, Type 2d
Neuropathy, Distal Hereditary Motor, Type Iid	Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant
Distal Spinal Muscular Atrophy With Calf Predominance	Neuronopathy, Distal Hereditary Motor, 2d
Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant	Dhmn Iid
Neuropathy, Motor, Distal, Hereditary, Type 2d

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12044	RNF125 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RNF125	RGD	RGD:1306757
Felis catus	RNF125	VGNC	VGNC:64667
Mus musculus	RNF125	MGD	MGI:1914914
Canis familiaris	RNF125	VGNC	VGNC:45627
Macaca mulatta	RNF125	VGNC	VGNC:104244
Bos taurus	RNF125	VGNC	VGNC:34017

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