RNF115 - ring finger protein 115 Gene

中文名称：无名指蛋白 115

种属: Homo sapiens

同用名: BCA2; ZFP364; ZNF364; RABRING7

基因 ID: 27246 | 基因类型: protein coding

关于 RNF115

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,738,868-145,824,095 (from NCBI)

This gene has 2 transcripts (splice variants), 256 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues.

功能概要

启用泛素蛋白转移酶活性。参与表皮生长因子受体信号通路的负调控；蛋白质自身泛素化；和泛素依赖性蛋白质分解代谢过程通过多泡体分选途径。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RNF115 基因产物(1)

mRNA	Protein	Name
NM_014455.4	NP_055270.1	E3 ubiquitin-protein ligase RNF115

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16925951	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	35343654	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	18819927	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	23418353	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: 通过直接分析推断	35343654	GOA
involved in protein K11-linked ubiquitination	IDA IDA: 通过直接分析推断	35343654	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	16288031	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: 通过突变表型推断	23418353	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in endoplasmic reticulum	IDA IDA: 通过直接分析推断	35343654	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF115 蛋白结构

zinc_ribbon_9

zf-RING_2

0
100
200
304 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase RNF115

RING-type E3 ubiquitin transferase RNF115

RNF115 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RNF115	Q9Y4L5	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	32296183
Intra	RNF115	Q9Y4L5	UBE2E2	Homo sapiens	Q96LR5	Y2H Prey Pooling	32296183
Intra	RNF115	Q9Y4L5	UBE2D2	Homo sapiens	P62837	Y2H Array	19690564
Intra	RNF115	Q9Y4L5	UBE2D3	Homo sapiens	P61077	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	UBE2D3	Homo sapiens	P61077	Validated Y2H	25416956
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	RNF115	Q9Y4L5	MDM4	Homo sapiens	O15151	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	MDM4	Homo sapiens	O15151	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Y2H	21516116
Intra	RNF115	Q9Y4L5	UBE2D1	Homo sapiens	P51668	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	UBE2D1	Homo sapiens	P51668	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	31515488
Intra	RNF115	Q9Y4L5	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brachydactyly, Type A3

Brachydactyly Type A3	BDA3
Brachydactyly-Clinodactyly	Brachymesophalangy V
Brachymesophalangy 5	Brachydactyly Clinodactyly

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy	Hemiplegic Cerebral Palsy
Congenital Hemiplegia	Hemiplegic Infantile Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic	Spastic Hemiplegia Cerebral Palsy
Hemiplegia, Spastic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12040	RNF115 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RNF115	RGD	RGD:1305315
Canis familiaris	RNF115	VGNC	VGNC:45624
Macaca mulatta	RNF115	VGNC	VGNC:76762
Bos taurus	RNF115	VGNC	VGNC:34013
Mus musculus	RNF115	MGD	MGI:1915095
Felis catus	RNF115	VGNC	VGNC:80343

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