1. Gene
  2. USP11 - ubiquitin specific peptidase 11 Gene

USP11 - ubiquitin specific peptidase 11 Gene

中文名称:泛素特异性肽酶 11

种属: Homo sapiens

同用名: UHX1

基因 ID: 8237 | 基因类型: protein coding

关于 USP11

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,233,009-47,248,328 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues and 71 paralogues. Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues.

功能概要

蛋白质泛素化控制许多细胞内过程,包括细胞周期进程、转录激活和信号转导。这个动态过程涉及泛素结合酶和去泛素化酶,添加和去除泛素。去泛素化酶是半胱氨酸蛋白酶,可特异性地从泛素缀合的蛋白质底物上切割泛素。该基因编码一种去泛素化酶,该酶位于染色体 Xp11.23 的基因簇中[RefSeq 提供,2008 年 7 月]

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating Enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

USP11 基因产物(1)

mRNA Protein Name
NM_001371072.1 NP_001358001.1 ubiquitin carboxyl-terminal hydrolase 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
15314155 GOA
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
28992046 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15314155 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
29628311 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
15314155 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
28992046 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15314155 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USP11 蛋白结构

DUSP

DUSP: DUSP domain (99 - 184)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (207 - 284)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (308 - 927)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 11

deubiquitinating enzyme 11

关联疾病

疾病名称 别名
Bronchiectasis

Polynesian Bronchiectasis

Kartagener Syndrome

Bronchiectasis Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USP11 RGD RGD:1303052
Felis catus USP11 VGNC VGNC:66865
Bos taurus USP11 VGNC VGNC:36711
Canis familiaris USP11 VGNC VGNC:54609
Mus musculus USP11 MGD MGI:2384312
Macaca mulatta USP11 VGNC VGNC:78734
Others USP11 NCBI