1. Gene
  2. PCGF6 - polycomb group ring finger 6 Gene

PCGF6 - polycomb group ring finger 6 Gene

中文名称:Polycomb 组无名指 6

种属: Homo sapiens

同用名: MBLR; RNF134

基因 ID: 84108 | 基因类型: protein coding

关于 PCGF6

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,302,796-103,351,140 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 6.3), fat (RPKM 4.5) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个环指基序,与多梳组 (PcG) 蛋白 RNF110/MEL-18 和 BMI1 的基序关系最密切。已知 PcG 蛋白可形成蛋白复合物并起到转录抑制因子的作用。这种蛋白质已被证明与一些 PcG 蛋白质相互作用并充当转录抑制因子。发现该蛋白质的活性受细胞周期依赖性磷酸化的调节。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PCGF6 基因产物(2)

mRNA Protein Name
NM_001011663.2 NP_001011663.1 polycomb group RING finger protein 6 isoform a
NM_032154.4 NP_115530.2 polycomb group RING finger protein 6 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21282530 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
26151332 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8521824 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PRC1 complex IDA
IDA: 通过直接分析推断
19636380 GOA
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PCGF6 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (134 - 172)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

polycomb group RING finger protein 6

Mel18 and Bmi1-like RING finger protein

PCGF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PCGF6 Q9BYE7 CBX7 Homo sapiens O95931
Pull Down
21282530
Intra PCGF6 Q9BYE7 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
33961781
Intra PCGF6 Q9BYE7 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
28514442
Intra PCGF6 Q9BYE7 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra PCGF6 Q9BYE7 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra PCGF6 Q9BYE7 RNF2 Homo sapiens Q99496
TAP
27705803
Intra PCGF6 Q9BYE7 RNF2 Homo sapiens Q99496
Anti Tag CoIP
28514442
Intra PCGF6 Q9BYE7 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra PCGF6 Q9BYE7 RING1 Homo sapiens Q06587
Y2H Array
22493164
Intra PCGF6 Q9BYE7 RING1 Homo sapiens Q06587
TAP
27705803
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Medulloblastoma Non-Wnt/Non-Shh
Medulloblastoma Shh Activated And Tp53 Wild-Type

Medulloblastoma Shh-Activated Tp53-Wildtype

Medulloblastoma Wnt Activated
Medulloblastoma Shh Activated
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCGF6 RGD RGD:1306904
Bos taurus PCGF6 VGNC VGNC:97296
Mus musculus PCGF6 MGD MGI:1918291
Canis familiaris PCGF6 VGNC VGNC:44304
Macaca mulatta PCGF6 VGNC VGNC:75662
Felis catus PCGF6 VGNC VGNC:64068