PCGF6 - polycomb group ring finger 6 Gene

中文名称：Polycomb 组无名指 6

种属: Homo sapiens

同用名: MBLR; RNF134

关于 PCGF6

功能概要

该基因编码的蛋白质包含一个环指基序，与多梳组 (PcG) 蛋白 RNF110/MEL-18 和 BMI1 的基序关系最密切。已知 PcG 蛋白可形成蛋白复合物并起到转录抑制因子的作用。这种蛋白质已被证明与一些 PcG 蛋白质相互作用并充当转录抑制因子。发现该蛋白质的活性受细胞周期依赖性磷酸化的调节。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]