2. Gene
  3. PCGF1 - polycomb group ring finger 1 Gene

PCGF1 - polycomb group ring finger 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Polycomb 组无名指 1

种属: Homo sapiens

同用名: NSPC1; RNF68; RNF3A-2; 2010002K04Rik

基因 ID: 84759 | 基因类型: protein coding

关于 PCGF1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,505,043-74,507,695 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 3.8) and 25 other tissues.

功能概要

PCGF1 是果蝇属多梳组基因的哺乳动物同系物，它作为转录抑制因子调节早期胚胎发育中的前后模式 (Nunes 等人，2001 [PubMed 11287196]) 。另见 PCGF2 (MIM 600346) 。[OMIM 提供，2008 年 8 月]

PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]

PCGF1 基因产物(1)

mRNA Protein Name
NM_032673.3 NP_116062.2 polycomb group RING finger protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16943429 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
16943429 GOA
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
26151332 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
16943429 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCGF1 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (47 - 85)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

polycomb group RING finger protein 1

RING finger protein 68

PCGF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PCGF1 Q9BSM1 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra PCGF1 Q9BSM1 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra PCGF1 Q9BSM1 CBX7 Homo sapiens O95931
Pull Down
21282530
Intra PCGF1 Q9BSM1 CBX6 Homo sapiens O95503
Pull Down
21282530
Intra PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
TAP
27705803
Intra PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
27505670
Intra PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
TAP
27505670
Intra PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
33961781
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
TAP
27705803
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Pull Down
16943429
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
TAP
27505670
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Anti Tag CoIP
27505670
Intra PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
TAP
27505670
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Y2H Array
22493164
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
TAP
27705803
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Anti Tag CoIP
22493164
Intra PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Pull Down
16943429
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Pull Down
16943429
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
16943429
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
TAP
27505670
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Bait CoIP
16943429
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
33961781
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
27505670
Intra PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
TAP
27705803
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13
Microphthalmia, Syndromic 2

Oculofaciocardiodental Syndrome

Ofcd Syndrome

MCOPS2

Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects

Syndromic Microphthalmia 2

Anop2

Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome

Maa2

Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects

Syndromic Microphthalmia Type 2

Oculo-Facio-Cardio-Dental Syndrome

Anop2, Formerly

Maa2, Formerly

Microphthalmia Syndromic 2

Oculo Facio Cardio Dental Syndrome

Microphthalmia, Syndromic, 2

Marashi-Gorlin Syndrome

Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects

Microphthalmia, Syndromic, Type 2
Syndromic Microphthalmia

Microphthalmia, Syndromic
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney

Childhood Kidney Clear Cell Sarcoma

Renal Clear Cell Sarcoma

Ccsk

Clear Cell Sarcoma Of The Kidney
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10145 PCGF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PCGF1 MGD MGI:1917087
Felis catus PCGF1 VGNC VGNC:81141
Canis familiaris PCGF1 VGNC VGNC:44300
Bos taurus PCGF1 VGNC VGNC:32626
Macaca mulatta PCGF1 VGNC VGNC:75640
Rattus norvegicus PCGF1 RGD RGD:1549782
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