2. Anti-infection
  3. Reverse Transcriptase
  4. PNR-7-02

PNR-7-02 抑制 Pol η 的功能，IC50 值接近 8 μM，相互作用于小指域。PNR-7-02 也是 hRev1 和 hpol lambda (λ) 抑制剂。PNR-7-02 与 Cisplatin (HY-17394) 协同杀死慢性髓性白血病和卵巢癌细胞系。PNR-7-02 是吲哚硫代巴比妥酸 (ITBA) 的衍生物，具有 N-萘酰基和吲哚环上的 5-氯取代基。

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PNR-7-02 Chemical Structure

PNR-7-02 Chemical Structure

CAS No. : 1633660-76-0

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PNR-7-02 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].

分子量

445.92

Formula

C24H16ClN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PNR-7-02 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNR-7-021633660-76-0Reverse TranscriptasePol ηhRev1hpol lambda (λ)chronic myeloid leukaemiaovarian cancer cell linesITBA derivativeInhibitorinhibitorinhibit

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目录号：
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