RPS4X - ribosomal protein S4 X-linked Gene

中文名称：核糖体蛋白 S4 X 连锁

种属: Homo sapiens

同用名: S4; CCG2; RPS4; SCAR; SCR10; DXS306

基因 ID: 6191 | 基因类型: protein coding

关于 RPS4X

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,272,042-72,277,248 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 1675.7), lymph node (RPKM 944.2) and 25 other tissues.

功能概要

细胞质核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码核糖体蛋白 S4，它是 40S 亚基的一个组成部分。核糖体蛋白 S4 是唯一已知由一个以上基因编码的核糖体蛋白，即该基因和核糖体蛋白 S4，Y 连锁 (RPS4Y) 。由这些基因编码的 2 种亚型并不相同，但在功能上是等同的。核糖体蛋白 S4 属于核糖体蛋白 S4E 家族。该基因不受 X 失活的影响。有人提出，核糖体蛋白 S4 基因的单倍体不足在特纳综合征中起作用；然而，这个假设是有争议的。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS4X 基因产物(1)

mRNA	Protein	Name
NM_001007.5	NP_000998.1	40S ribosomal protein S4, X isoform

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24965446	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	8358435	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	1795030	GOA
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	1795030	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: 通过直接分析推断	34516797	GOA
involved in translation	IMP IMP: 通过突变表型推断	8358435	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasmic ribonucleoprotein granule	IDA IDA: 通过直接分析推断	15121898	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: 通过直接分析推断	8706699	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	17289661	GOA
located in ribosome	IDA IDA: 通过直接分析推断	8139551	GOA
part of small ribosomal subunit	IDA IDA: 通过直接分析推断	8139551	GOA
part of small-subunit processome	IDA IDA: 通过直接分析推断	34516797	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS4X 蛋白结构

RS4NT

Ribosomal_S4e

KOW

0
100
200
263 a.a.

蛋白主名

其他名称

40S ribosomal protein S4, X isoform

cell cycle gene 2

关联疾病

疾病名称

别名

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12244	RPS4X Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RPS4X	MGD	MGI:98158
Rattus norvegicus	RPS4X	RGD	RGD:2324318

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPS4X - ribosomal protein S4 X-linked Gene

关于 RPS4X

功能概要

RPS4X 基因产物(1)

RPS4X 蛋白结构

关联疾病

直系同源

热门区域

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RPS4X - ribosomal protein S4 X-linked Gene

关于 RPS4X

功能概要

RPS4X 基因产物(1)

RPS4X 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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