E2F8 - E2F transcription factor 8 Gene

中文名称：E2F 转录因子 8

种属: Homo sapiens

同用名: E2F-8

基因 ID: 79733 | 基因类型: protein coding

关于 E2F8

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,224,063-19,241,655 (from NCBI)

This gene has 5 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.6), lymph node (RPKM 3.5) and 14 other tissues.

功能概要

该基因编码转录因子家族的一个成员，该家族调节细胞周期进展所需的基因表达。编码的蛋白质通过确保细胞核在适当的时间分裂来调节从 G1 期到 S 期的进展。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

E2F8 基因产物(3)

mRNA	Protein	Name
NM_001256371.2	NP_001243300.1	transcription factor E2F8
NM_001256372.1	NP_001243301.1	transcription factor E2F8
NM_024680.4	NP_078956.2	transcription factor E2F8

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	22903062	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	16179649	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16179649	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22903062	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18202719	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16179649	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22903062	GOA
involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	22903062	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

E2F8 蛋白结构

E2F_TDP

0
200
400
600
800
867 a.a.

蛋白主名

其他名称

transcription factor E2F8

E2F family member 8

E2F8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	E2F8	A0AVK6	E2F7	Homo sapiens	Q96AV8	Anti Bait CoIP	18202719
Intra	E2F8	A0AVK6	E2F7	Homo sapiens	Q96AV8	Anti Tag CoIP	18202719
Intra	E2F8	A0AVK6	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	E2F8	A0AVK6	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	E2F8	A0AVK6	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	E2F8	A0AVK6	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	E2F8	A0AVK6	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	E2F8	A0AVK6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	E2F8	A0AVK6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	E2F8	A0AVK6	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	E2F8	A0AVK6	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	E2F8	A0AVK6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	E2F8	A0AVK6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	E2F8	A0AVK6	STUB1	Homo sapiens	Q9UNE7	Y2H Prey Pooling	32296183
Intra	E2F8	A0AVK6	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32296183
Intra	E2F8	A0AVK6	STUB1	Homo sapiens	Q9UNE7	Y2H Array	32296183
Intra	E2F8	A0AVK6	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	E2F8	A0AVK6	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	E2F8	A0AVK6	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	E2F8	A0AVK6	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956
Intra	E2F8	A0AVK6	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	E2F8	A0AVK6	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	E2F8	A0AVK6	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	E2F8	A0AVK6	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	E2F8	A0AVK6	SNCA	Homo sapiens	P37840	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Bilateral Retinoblastoma

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04117	E2F8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	E2F8	VGNC	VGNC:71900
Canis familiaris	E2F8	VGNC	VGNC:40170
Felis catus	E2F8	VGNC	VGNC:61699
Rattus norvegicus	E2F8	RGD	RGD:1308091
Bos taurus	E2F8	VGNC	VGNC:28292
Mus musculus	E2F8	MGD	MGI:1922038

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

E2F8 - E2F transcription factor 8 Gene

关于 E2F8

功能概要

E2F8 基因产物(3)

E2F8 蛋白结构

E2F8 蛋白互作信息

关联疾病

直系同源

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E2F8 - E2F transcription factor 8 Gene

关于 E2F8

功能概要

E2F8 基因产物(3)

E2F8 蛋白结构

E2F8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z