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  3. E2F7 - E2F transcription factor 7 Gene

E2F7 - E2F transcription factor 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：E2F 转录因子 7

种属: Homo sapiens

基因 ID: 144455 | 基因类型: protein coding

关于 E2F7

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:77,021,251-77,065,569 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 7 paralogues. Broad expression in testis (RPKM 1.6), bone marrow (RPKM 1.5) and 16 other tissues.

功能概要

E2F 转录因子，如 E2F7，在细胞周期进程的调节中发挥重要作用 (Di Stefano 等人，2003 [PubMed 14633988]) 。[OMIM 提供，2008 年 5 月]

E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]

E2F7 基因产物(1)

mRNA Protein Name
NM_203394.3 NP_976328.2 transcription factor E2F7
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
22903062 GOA
enables DNA-binding transcription repressor activity IDA
IDA: 通过直接分析推断
22802528 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22903062 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15133492 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18202719 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
IDA: 通过直接分析推断
22802528 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22802528 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22903062 GOA
involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
22903062 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

E2F7 蛋白结构

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (142 - 211)

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (282 - 367)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
蛋白主名 其他名称

transcription factor E2F7

E2F-7

E2F7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
E2F7 Q96AV8 E2F8 Homo sapiens A0AVK6
Anti Tag CoIP
18202719
种属内
E2F7 Q96AV8 E2F7 Homo sapiens Q96AV8
Anti Tag CoIP
15133492
种属内
E2F7 Q96AV8 E2F7 Homo sapiens Q96AV8
Pull Down
15133492
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina
Bilateral Retinoblastoma
Soft Palate Cancer

Malignant Tumor Of Soft Palate

Malignant Tumor Of The Soft Palate

Palate Cancer Soft Palate
Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma
Ocular Cancer

Eye Neoplasm

Eye Carcinoma

Eye Cancer

Eye Neoplasms

Malignant Eye Neoplasm

Neoplasm Of Eye

Neoplasm Of Eye Proper

Ocular Tumor

Carcinoma Of Eye

Ocular Carcinoma

Malignant Tumor Of Eye
Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04116 E2F7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus E2F7 MGD MGI:1289147
Canis familiaris E2F7 VGNC VGNC:40169
Felis catus E2F7 VGNC VGNC:61698
Bos taurus E2F7 VGNC VGNC:28291
Macaca mulatta E2F7 VGNC VGNC:71891
Rattus norvegicus E2F7 RGD RGD:1310258
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