CDS2 - CDP-diacylglycerol synthase 2 Gene

中文名称：CDP-甘油二酯合酶 2

种属: Homo sapiens

关于 CDS2

功能概要

磷酸肌醇的分解产物是普遍存在的第二信使，在许多 G 蛋白偶联受体和酪氨酸激酶的下游发挥作用，调节细胞生长、钙代谢和蛋白激酶 C 活性。该基因编码一种酶，该酶通过催化磷脂酸转化为 CDP-二酰基甘油来调节可用于信号传导的磷脂酰肌醇的量。这种酶是一种完整的膜蛋白，定位于两个亚细胞结构域，线粒体内膜的基质侧被认为参与磷脂酰甘油和心磷脂的合成，以及内质网的细胞质侧，它在磷脂酰肌醇生物合成中发挥作用。已在人类中鉴定出编码该酶的两个基因，一个对应于人类染色体 4q21，另一个对应于 20p13。[RefSeq 提供，2008 年 7 月]

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an Enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This Enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this Enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]