SF3B3 - splicing factor 3b subunit 3 Gene

中文名称：剪接因子 3b 亚基 3

种属: Homo sapiens

同用名: RSE1; SAP130; SF3b130; STAF130

关于 SF3B3

功能概要

该基因编码剪接因子 3b 蛋白复合物的第 3 亚基。剪接因子 3b 与剪接因子 3a 和一个 12S RNA 单元一起形成 U2 小核糖核蛋白复合物 (U2 snRNP) 。剪接因子 3b/3a 复合物以序列独立的方式结合内含子分支位点上游的前体 mRNA，并可能将 U2 snRNP 锚定到前体 mRNA。剪接因子 3b 也是较小的 U12 型剪接体的一个组成部分。亚基 3 也被确定为 STAGA (SPT3-TAF (II) 31-GCN5L 乙酰化酶) 转录共激活因子-HAT (组蛋白乙酰转移酶) 复合物和 TFTC (无 TATA 结合蛋白的 TAF (II) -含复合物) 。这些复合物可能在染色质修饰、转录、剪接和 DNA 修复中起作用。[RefSeq 提供，2008 年 7 月]

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (Histone Acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]