MRI1 - methylthioribose-1-phosphate isomerase 1 Gene

中文名称：1-磷酸甲基硫核糖异构酶 1

种属: Homo sapiens

同用名: M1Pi; MRDI; MTNA; Ypr118w

关于 MRI1

功能概要

该酶通过催化甲基硫核糖-1-磷酸和甲基硫核酮糖-1-磷酸的相互转化在甲硫氨酸补救途径中发挥作用。编码蛋白的表达升高与转移性黑色素瘤相关，并且该蛋白独立于其酶活性促进黑色素瘤细胞侵袭。该基因的突变可能与消失的白质病 (VMWD) 有关。[RefSeq 提供，2016 年 7 月]

This Enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]