LOXL4 - lysyl oxidase like 4 Gene

中文名称：赖氨酰氧化酶样 4

种属: Homo sapiens

同用名: LOXC

基因 ID: 84171 | 基因类型: protein coding

关于 LOXL4

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:98,247,690-98,268,194 (from NCBI)

This gene has 1 transcript (splice variant), 288 orthologues and 15 paralogues. Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues.

功能概要

该基因编码赖氨酰氧化酶基因家族的一个成员。该家族的原型成员对结缔组织的生物发生至关重要，编码细胞外铜依赖性胺氧化酶，催化胶原蛋白和弹性蛋白交联形成的第一步。 C 末端高度保守的氨基酸序列似乎足以维持胺氧化酶活性，表明每个家族成员都可能保留此功能。 N 末端的保守性很差，可能在发育调节、衰老、肿瘤抑制、细胞生长控制和趋化性方面赋予每个家族成员额外的作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL4 基因产物(1)

mRNA	Protein	Name
NM_032211.7	NP_115587.6	lysyl oxidase homolog 4 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein-lysine 6-oxidase activity	IDA IDA: 通过直接分析推断	14551188	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of receptor complex	IDA IDA: 通过直接分析推断	23382219	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LOXL4 蛋白结构

SRCR

Lysyl_oxidase

0
200
400
600
756 a.a.

蛋白主名

其他名称

lysyl oxidase homolog 4

lysyl oxidase related C

LOXL4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LOXL4	Q96JB6	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	LOXL4	Q96JB6	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	LOXL4	Q96JB6	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	CCT6B	Homo sapiens	Q92526	Anti Tag CoIP	33961781
Intra	LOXL4	Q96JB6	CCT6B	Homo sapiens	Q92526	Anti Tag CoIP	28514442
Intra	LOXL4	Q96JB6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	LOXL4	Q96JB6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	LOXL4	Q96JB6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	LOXL4	Q96JB6	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	LOXL4	Q96JB6	TRIP13	Homo sapiens	Q15645	Y2H Pooling	19060904
Intra	LOXL4	Q96JB6	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	LOXL4	Q96JB6	TRIP13	Homo sapiens	Q15645	Y2H Array	19060904
Intra	LOXL4	Q96JB6	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LOXL4	Q96JB6	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	LOXL4	Q96JB6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LOXL4	Q96JB6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LOXL4	Q96JB6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LOXL4	Q96JB6	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Phacogenic Glaucoma

Urofacial Syndrome 1

Urofacial Syndrome	Ochoa Syndrome
Hydronephrosis With Peculiar Facial Expression	Ufs
Inverted Smile And Occult Neuropathic Bladder	Partial Facial Palsy With Urinary Abnormalities
UFS1	Urofacial Ochoa'S Syndrome
Urofacial Syndrome Type 1	Facial Palsy, Partial, With Urinary Abnormalities
Hydronephrosis-Inverted Smile	Inverted Smile-Neurogenic Bladder
Hydronephrosis-Inverted Smile Syndrome	Inverted Smile-Neurogenic Bladder Syndrome
Partial Facial Palsy Partial With Urinary Abnormalities	Urologic Diseases

Scoliosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.83%	否
HY-151498	PXS-4787	Inhibitor	/	否
HY-151498A	PXS-4787 hydrochloride	Inhibitor	/	否
HY-151499	PXS-6302	Inhibitor	/	否
HY-RS07744	LOXL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LOXL4	MGD	MGI:1914823
Canis familiaris	LOXL4	VGNC	VGNC:42741
Felis catus	LOXL4	VGNC	VGNC:63260
Bos taurus	LOXL4	VGNC	VGNC:55958
Rattus norvegicus	LOXL4	RGD	RGD:1308588
Others	LOXL4	NCBI

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