ANXA4 - annexin A4 Gene

中文名称：膜联蛋白 A4

种属: Homo sapiens

同用名: ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274

关于 ANXA4

功能概要

膜联蛋白 IV (ANX4) 属于钙依赖性磷脂结合蛋白的膜联蛋白家族。尽管它们的功能仍未明确定义，但膜联蛋白家族的几个成员与胞吐和胞吞途径的膜相关事件有关。 ANX4 与其家族的其他成员有 45% 到 59% 的同一性，并且共享相似的大小和外显子内含子组织。从人胎盘中分离出来的 ANX4 编码的蛋白质可能与 ATP 相互作用，具有体外抗凝活性，还能抑制磷脂酶 A2 活性。 ANX4 几乎只在上皮细胞中表达。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 3 月]

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits Phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]