OSGIN1 - oxidative stress induced growth inhibitor 1 Gene

中文名称：氧化应激诱导生长抑制因子 1

种属: Homo sapiens

同用名: BDGI; OKL38

关于 OSGIN1

功能概要

该基因编码一种调节细胞死亡的氧化应激反应蛋白。该基因的表达受 p53 调节，并由 DNA 损伤诱导。该蛋白通过诱导线粒体释放细胞色素 c 来调节细胞凋亡。它似乎也是炎症和抗炎分子的关键调节剂。这种蛋白质的丢失与不受控制的细胞生长和肿瘤形成相关。该基因与邻近的上游丙二酰辅酶 A 脱羧酶 (MLYCD) 基因之间存在自然发生的通读转录，但通读转录物不太可能产生蛋白质产物。[RefSeq 提供，2011 年 8 月]

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates Apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]