BCAR3 - BCAR3 adaptor protein, NSP family member Gene

中文名称：BCAR3 衔接蛋白，NSP 家族成员

种属: Homo sapiens

同用名: MIG7; NSP2; AND-34; SH2D3B

基因 ID: 8412 | 基因类型: protein coding

关于 BCAR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,561,741-93,847,219 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues.

功能概要

乳腺肿瘤最初依赖于雌激素来生长和发展，并且可以被抗雌激素药物如他莫昔芬抑制。然而，乳腺癌发展成为抗雌激素抵抗。乳腺癌抗雌激素抗性基因 3 在寻找参与雌激素抗性发展的基因时被发现。该基因编码细胞内信号转导的一个成分，该成分可导致人乳腺癌细胞中不依赖雌激素的增殖。该蛋白质包含一个推定的 Src 同源 2 (SH2) 结构域，这是细胞酪氨酸激酶信号分子的标志，并且与细胞分裂周期蛋白 CDC48 部分同源。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 5 月]

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast Cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast Cancer cells. The protein contains a putative Src homology 2 (SH2) domain, a hall MARK of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAR3 基因产物(33)

mRNA	Protein	Name
NM_001261408.2	NP_001248337.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261409.1	NP_001248338.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261410.2	NP_001248339.1	breast cancer anti-estrogen resistance protein 3 isoform 2
NM_001308251.1	NP_001295180.1	breast cancer anti-estrogen resistance protein 3 isoform 3
NM_001412043.1	NP_001398972.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412044.1	NP_001398973.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412045.1	NP_001398974.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412046.1	NP_001398975.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412048.1	NP_001398977.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412049.1	NP_001398978.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412050.1	NP_001398979.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412051.1	NP_001398980.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412052.1	NP_001398981.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412054.1	NP_001398983.1	breast cancer anti-estrogen resistance protein 3 isoform 4
NM_001412055.1	NP_001398984.1	breast cancer anti-estrogen resistance protein 3 isoform 5
NM_001412056.1	NP_001398985.1	breast cancer anti-estrogen resistance protein 3 isoform 6
NM_001412057.1	NP_001398986.1	breast cancer anti-estrogen resistance protein 3 isoform 7
NM_001412058.1	NP_001398987.1	breast cancer anti-estrogen resistance protein 3 isoform 8
NM_001412059.1	NP_001398988.1	breast cancer anti-estrogen resistance protein 3 isoform 9
NM_001412060.1	NP_001398989.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412061.1	NP_001398990.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412062.1	NP_001398991.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412064.1	NP_001398993.1	breast cancer anti-estrogen resistance protein 3 isoform 12
NM_001412065.1	NP_001398994.1	breast cancer anti-estrogen resistance protein 3 isoform 13
NM_001412066.1	NP_001398995.1	breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412067.1	NP_001398996.1	breast cancer anti-estrogen resistance protein 3 isoform 15
NM_001412072.1	NP_001399001.1	breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412073.1	NP_001399002.1	breast cancer anti-estrogen resistance protein 3 isoform 16
NM_001412074.1	NP_001399003.1	breast cancer anti-estrogen resistance protein 3 isoform 17
NM_001412075.1	NP_001399004.1	breast cancer anti-estrogen resistance protein 3 isoform 18
NM_001412076.1	NP_001399005.1	breast cancer anti-estrogen resistance protein 3 isoform 19
NM_001412077.1	NP_001399006.1	breast cancer anti-estrogen resistance protein 3 isoform 8
NM_003567.4	NP_003558.1	breast cancer anti-estrogen resistance protein 3 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinase binding	IPI IPI: 通过物理相互作用推断	18722344	GOA
enables phosphotyrosine residue binding	IMP IMP: 通过突变表型推断	24216110	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16273093	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endothelin receptor signaling pathway	IMP IMP: 通过突变表型推断	19086031	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	18722344	GOA
involved in insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	24216110	GOA
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	19086031	GOA
involved in positive regulation of MAPK cascade	IMP IMP: 通过突变表型推断	24216110	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	18722344	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCAR3 蛋白结构

SH2

RasGEF

0
200
400
600
825 a.a.

蛋白主名

其他名称

breast cancer anti-estrogen resistance protein 3

BCAR3, NSP family adaptor protein

BCAR3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	BCAR3	O75815	GAS8	Homo sapiens	O95995	Validated Y2H	32296183
Intra	BCAR3	O75815	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	BCAR3	O75815	KIT	Homo sapiens	P10721	FPS	24728074
Intra	BCAR3	O75815	NEDD9	Homo sapiens	Q14511	Anti Tag CoIP	33961781
Intra	BCAR3	O75815	NEDD9	Homo sapiens	Q14511	Validated Y2H	25416956
Intra	BCAR3	O75815	NEDD9	Homo sapiens	Q14511	Anti Tag CoIP	28514442
Intra	BCAR3	O75815	NEDD9	Homo sapiens	Q14511	Y2H Array	25416956
Intra	BCAR3	O75815	FUS	Homo sapiens	P35637	Validated Y2H	32814053
Intra	BCAR3	O75815	FUS	Homo sapiens	P35637	Y2H Pooling	32814053
Intra	BCAR3	O75815	FUS	Homo sapiens	P35637	Anti Bait CoIP	17353931
Intra	BCAR3	O75815	FUS	Homo sapiens	P35637	Y2H Array	32814053
Intra	BCAR3	O75815	IRS1	Homo sapiens	P35568	Y2H Array	25814554
Intra	BCAR3	O75815	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	BCAR3	O75815	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	BCAR3	O75815	UBASH3A	Homo sapiens	P57075-2	Validated Y2H	32296183
Intra	BCAR3	O75815	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	32296183
Intra	BCAR3	O75815	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	25640309

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Estrogen Resistance

Estrogen Resistance Syndrome	ESTRR
Estrogen Insensitivity

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01398	BCAR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	BCAR3	VGNC	VGNC:70235
Mus musculus	BCAR3	MGD	MGI:1352501
Felis catus	BCAR3	VGNC	VGNC:69195
Canis familiaris	BCAR3	VGNC	VGNC:49077
Rattus norvegicus	BCAR3	RGD	RGD:1311688
Bos taurus	BCAR3	VGNC	VGNC:53850

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BCAR3 - BCAR3 adaptor protein, NSP family member Gene

关于 BCAR3

功能概要

BCAR3 基因产物(33)

BCAR3 蛋白结构

BCAR3 蛋白互作信息

关联疾病

直系同源

热门区域

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BCAR3 - BCAR3 adaptor protein, NSP family member Gene

关于 BCAR3

功能概要

BCAR3 基因产物(33)

BCAR3 蛋白结构

BCAR3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z