2. Gene
  3. NEDD9 - neural precursor cell expressed, developmentally down-regulated 9 Gene

NEDD9 - neural precursor cell expressed, developmentally down-regulated 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经前体细胞表达，发育下调 9

种属: Homo sapiens

同用名: CAS2; CASL; HEF1; CAS-L; CASS2

基因 ID: 4739 | 基因类型: protein coding

关于 NEDD9

Cytogenetic location: 6p24.2 Genomic coordinates (GRCh38): 6:11,183,298-11,382,348 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in lung (RPKM 35.3), placenta (RPKM 25.4) and 22 other tissues.

功能概要

该基因编码的蛋白质是 CRK 相关底物家族的成员。该家族的成员是介导信号转导通路的蛋白质-蛋白质相互作用的粘附对接分子。该蛋白是一种粘着斑蛋白，可作为支架调节信号复合物，这些信号复合物在细胞附着、迁移和侵袭以及细胞凋亡和细胞周期中很重要。据报道，这种蛋白质在癌症转移中也有作用。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as Apoptosis and the cell cycle. This protein has also been reported to have a role in Cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

NEDD9 基因产物(4)

mRNA Protein Name
NM_001142393.2 NP_001135865.1 enhancer of filamentation 1 isoform 3
NM_001271033.2 NP_001257962.1 enhancer of filamentation 1 isoform 4
NM_006403.4 NP_006394.1 enhancer of filamentation 1 isoform 1
NM_182966.4 NP_892011.2 enhancer of filamentation 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9360983 GOA
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
18256281 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cilium disassembly IMP
IMP: 通过突变表型推断
17604723 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
18256281 GOA
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
18256281 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
18256281 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary basal body IDA
IDA: 通过直接分析推断
17604723 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
19103205 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
16394104 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29899023 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEDD9 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (10 - 60)

Serine_rich

Serine_rich: Serine rich protein interaction domain (404 - 559)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (617 - 828)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
蛋白主名 其他名称

enhancer of filamentation 1

Cas scaffolding protein family member 2

NEDD9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NEDD9 Q14511 PRR20C Homo sapiens P86479
Y2H Prey Pooling
25416956
Intra NEDD9 Q14511 REL Homo sapiens Q04864
Y2H Array
25416956
Intra NEDD9 Q14511 NFKBIA Homo sapiens P25963
Y2H Prey Pooling
25416956
Intra NEDD9 Q14511 NFKBIA Homo sapiens P25963
Y2H Array
25416956
Intra NEDD9 Q14511 BCAR3 Homo sapiens O75815
Y2H Prey Pooling
25416956
Intra NEDD9 Q14511 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra NEDD9 Q14511 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra NEDD9 Q14511 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra NEDD9 Q14511 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra NEDD9 Q14511 RFX6 Homo sapiens Q8HWS3
Validated Y2H
25416956
Intra NEDD9 Q14511 RFX6 Homo sapiens Q8HWS3
Y2H Array
25416956
Intra NEDD9 Q14511 NAB2 Homo sapiens Q15742
Y2H Array
25416956
Intra NEDD9 Q14511 NAB2 Homo sapiens Q15742
Y2H
21516116
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Palmoplantar Keratoderma And Congenital Alopecia 2

Cataract-Alopecia-Sclerodactyly Syndrome

Cass

Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia

PPKCA2

Autosomal Recessive Palmoplantar Hyperkeratosis And Congenital Alopecia

Palmoplantar Keratoderma And Congenital Alopecia, Wallis Type

Ppk-Ca, Wallis Type

Cataract, Alopecia, Sclerodactyly

Ppkca, Wallis Type

Ppkca Wallis Type

Cataract, Alopecia, Sclerodactyly Syndrome
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09182 NEDD9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NEDD9 VGNC VGNC:75304
Bos taurus NEDD9 VGNC VGNC:31984
Felis catus NEDD9 VGNC VGNC:68453
Mus musculus NEDD9 MGD MGI:97302
Canis familiaris NEDD9 VGNC VGNC:43722
Rattus norvegicus NEDD9 RGD RGD:1306276
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