2. Gene
  3. ADAMTSL5 - ADAMTS like 5 Gene

ADAMTSL5 - ADAMTS like 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：亚当斯样 5

种属: Homo sapiens

同用名: THSD6

基因 ID: 339366 | 基因类型: protein coding

关于 ADAMTSL5

This gene has 11 transcripts (splice variants), 188 orthologues and 25 paralogues. Broad expression in endometrium (RPKM 3.3), heart (RPKM 2.8) and 21 other tissues.

功能概要

启用肝素结合活性和微纤维结合活性。位于细胞外区和微纤维中。 [由基因组资源联盟提供，2022 年 4 月]

Enables heparin binding activity and microfibril binding activity. Located in extracellular region and microfibril. [provided by Alliance of Genome Resources, Apr 2022]

ADAMTSL5 基因产物(2)

mRNA Protein Name
NM_001367197.1 NP_001354126.1 ADAMTS-like protein 5 isoform 1 precursor
NM_213604.3 NP_998769.2 ADAMTS-like protein 5 isoform 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparin binding IDA
IDA: 通过直接分析推断
23010571 GOA
enables microfibril binding IDA
IDA: 通过直接分析推断
23010571 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
23010571 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
23010571 GOA
located in microfibril IDA
IDA: 通过直接分析推断
23010571 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAMTSL5 蛋白结构

TSP_1

TSP_1: Thrombospondin type 1 domain (39 - 86)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (194 - 301)

NTR

NTR: UNC-6/NTR/C345C module (365 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
蛋白主名 其他名称

ADAMTS-like protein 5

ADAMTSL-5

ADAMTSL5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADAMTSL5 Q6ZMM2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
ADAMTSL5 Q6ZMM2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
ADAMTSL5 Q6ZMM2 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
种属内
ADAMTSL5 Q6ZMM2 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
种属内
ADAMTSL5 Q6ZMM2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
种属内
ADAMTSL5 Q6ZMM2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Isolated Ectopia Lentis

Familial Ectopia Lentis

Ectopia Lentis

Ectopia Lentis Syndrome

Lens Subluxation

Iel

Congenital Ectopia Lentis

Subluxation Of Lens

Ectopia Lentis, Isolated

Ectopia Lentis Isolated
Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3

Autoimmune Lymphoproliferative Syndrome Type 3

Immunodeficiency, Common Variable, 9, Formerly

Cvid9, Formerly

Autoimmune Lymphoproliferative Syndrome Type Iii

Autoimmune Lymphoproliferative Syndrome 3

Cvid9

Immunodeficiency, Common Variable, 9

Type 3 Autoimmune Lymphoproliferative Syndrome

Immunodeficiency, Variable, Common, Type 9
Peters-Plus Syndrome

Krause-Kivlin Syndrome

Peters Plus Syndrome

Peters Anomaly

Irido-Corneo-Trabecular Dysgenesis

PTRPLS

Peters Anomaly With Short-Limb Dwarfism

Peters Anomaly-Short Limb Dwarfism Syndrome

Peters Anomaly With Short Limb Dwarfism

Peters Congenital Glaucoma

Krause-Van Schooneveld-Kivlin Syndrome

Peters' Plus Syndrome

Peters'-Plus Syndrome

Anomaly Peters
Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd
Weill-Marchesani Syndrome

Gemss Syndrome

Spherophakia-Brachymorphia Syndrome

Marchesani-Weill Syndrome

Wms

Congenital Mesodermal Dystrophy

Mesodermal Dysmorphodystrophy, Congenital

Spherophakia Brachymorphia Syndrome

Mesodermal Dysmorphodystrophy Congenital

Wm Syndrome

Brachydactyly-Spherophakia Syndrome

Brachymorphy With Spherophakia Syndrome

Congenital Mesodermal Dysmorphodystrophy

Marchesani Syndrome

Weill-Marchesani Syndrome, Autosomal Recessive

Weill-Marchesani Syndrome, Autosomal Dominant
Acromicric Dysplasia

ACMICD

Acromicric Skeletal Dysplasia

Dysplasia, Acromicric
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00314 ADAMTSL5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADAMTSL5 RGD RGD:1305607
Felis catus ADAMTSL5 VGNC VGNC:59603
Mus musculus ADAMTSL5 MGD MGI:1913798
Canis familiaris ADAMTSL5 VGNC VGNC:37609
Bos taurus ADAMTSL5 VGNC VGNC:106630
Macaca mulatta ADAMTSL5 VGNC VGNC:69540
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