2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC HSP
  4. HDAC6/HSP90-IN-1

HDAC6/HSP90-IN-1 (化合物17) 是一种有效的选择性的 HDAC6 和 HSP90 的双重抑制剂，IC50 值分别为 4.3 和 46.8 nM。HDAC6/HSP90-IN-1 可下调 INF-γ 处理的 H1975 肺癌细胞中 PD-L1 的表达。HDAC6/HSP90-IN-1 在 H1975 异种移植小鼠中抑制肿瘤生长。

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HDAC6/HSP90-IN-1 Chemical Structure

HDAC6/HSP90-IN-1 Chemical Structure

CAS No. : 2411955-43-4

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HDAC6/HSP90-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

IC50 & Target

HDAC6

4.32 nM (IC50)

HSP90

46.8 nM (IC50)

HDAC3

1312 nM (IC50)

HDAC1

1878 nM (IC50)

HDAC8

3720 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.76 μM
Compound: 17
Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
[PMID: 32058238]
NCI-H1975 GI50
0.52 μM
Compound: 17
Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
[PMID: 32058238]
分子量

511.61

Formula

C28H37N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6/HSP90-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

HDAC6/HSP90-IN-12411955-43-4HDACHSPHistone deacetylasesHeat shock proteinsNSCLC cellsH1975 cellsIsoindolineProgrammed death-ligand 1 (PD-L1)Histone deacetylaseHeat shock proteinLung cancerimmunosuppressiveInhibitorinhibitorinhibit

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产品名称：
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