2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease Apoptosis
  3. HDAC HSP Apoptosis
  4. HDAC6/HSP90-IN-2

HDAC6/HSP90-IN-2 (compound 6e) 是 HDAC6 和 Hsp90 的双抑制剂，其 IC50 值分别为 106 nM 和 61 nM。HDAC6/HSP90-IN-2 可用于癌症的研究。

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HDAC6/HSP90-IN-2 Chemical Structure

HDAC6/HSP90-IN-2 Chemical Structure

CAS No. : 2803866-22-8

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HDAC6/HSP90-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer[1].

IC50 & Target

HDAC6

106 nM (IC50)

HDAC1

654.5 nM (IC50)

HDAC3

1539 nM (IC50)

HDAC7

1691 nM (IC50)

体外研究
(In Vitro)

HDAC6/HSP90-IN-2 (compound 6e) (0.05-2 μM; 24 h) effects HSP90, HDAC6 and signaling pathways regulated by Hsp90 dose-dependently[1].
HDAC6/HSP90-IN-2 (compound 6e) (2 μM; 24 h) promotes the acetylation of HSP90[1].
HDAC6/HSP90-IN-2 (compound 6e) (0-100 μM; 24-72 h) inhibits the growth of H1975 non-small cell lung cancer cells[1].
HDAC6/HSP90-IN-2 (compound 6e) (0-2 μM; 24 h) induces apoptosis of H1975 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6/HSP90-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: H1975 cells
Concentration: 0.05, 0.1, 0.5, 1 and 2 μM
Incubation Time: 24 hours
Result: Showed inhibitory effect to Hsp90 and HDACs dose-dependently and increased the expression levels of Hsp70 and Hsp90 probably by activates HSF1.

Western Blot Analysis[1]

Cell Line: H1975 cells
Concentration: 2 μM
Incubation Time: 24 hours
Result: Promoted the acetylation of Hsp90 by inhibiting HDAC6, and increased the acetylation at K294 residue of Hsp90.

Apoptosis Analysis[1]

Cell Line: H1975 cells
Concentration: 0, 0.5, 1 and 2 μM
Incubation Time: 24 hours
Result: Induced early and late apoptosis of H1975 cells dose-dependently.

Cell Viability Assay[1]

Cell Line: H1975 cells
Concentration: 0-100 μM
Incubation Time: 24, 48 and 72 h
Result: Inhibited the growth of H1975 non-small cell lung cancer cells with a GI50 value of 1.7 μM.
体内研究
(In Vivo)

HDAC6/HSP90-IN-2 (25-50 mg/kg; i.p. every weekdays for 6 weeks) exhibits antitumor activity of in NOD-scid IL2Rgammanull (NSG) mice with xenotransplantation of H1975 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-scid IL2Rgammanull (NSG) mouse with H1975 cells xenograft[1]
Dosage: 25-50 mg/kg
Administration: Intraperitoneal injection; 25-50 mg/kg for every weekdays; for 6 weeks
Result: Delayed tumor growth after 2 weeks and reduced the growth rates of tumors in mice.
分子量

358.39

Formula

C19H22N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6/HSP90-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6/HSP90-IN-22803866-22-8HDACHSPApoptosisHistone deacetylasesHeat shock proteinslung cancerresistancesmall moleculedual inhibitorH1975 NSCLC xenograft modelapoptosisInhibitorinhibitorinhibit

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