2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-37

HDAC-IN-37 是一种有效的 HDAC 抑制剂，对 HDAC1、HDAC3、HDAC8 和 HDAC6 的 IC50 分别为 0.0551 μM、1.24 μM、0.948 μM 和 34.2 μM。HDAC-IN-37 能缓慢诱导组蛋白乙酰化。HDAC-IN-37 抑制细胞由 G1 期向 S 期转变，诱导早期细胞凋亡 (apoptosis)。

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HDAC-IN-37 Chemical Structure

HDAC-IN-37 Chemical Structure

CAS No. : 2766466-56-0

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HDAC-IN-37 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis[1].

IC50 & Target[1]

HDAC1

55.1 nM (IC50)

HDAC3

1.24 μM (IC50)

HDAC8

0.948 μM (IC50)

HDAC6

34.2 μM (IC50)

体外研究
(In Vitro)

HDAC-IN-37 (compound 9d) exhibits the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC50s of 0.50, 0.38, 0.12 μM, respectively[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) significantly induces the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells[1].
HDAC-IN-37 (0 - 10 μM; 24 hours) induces cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis[1].
HDAC-IN-37 (0 - 10 μM; 6, 12, 24 hours) causes G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression[1].
HDAC-IN-37 (0, 0.1, 0.5, 1, 5 and 10 μM; 0, 6, 12, 24, 36, 48 hours) down-regulates the levels of CDK2, Cyclin D1 and the up-regulates P21 with dose- and time-dependent manners in HCT-116 cells, and decreases Bcl-2 of Bcl-2 family in dose- and time-dependent manners[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-37 相关抗体:

Cell Proliferation Assay

Cell Line: HCT-116, MDA-MB-231, HepG2, A549, SGC7901 and K562[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Exhibited the potent antiproliferative activities on the HCT116, MDA-MB-231, K562 cell lines at IC50 of 0.50, 0.38, 0.12 μM, respectively.

Western Blot Analysis

Cell Line: HCT-116[1]
Concentration: 0, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time: 24 hours
Result: Significantly induced the accumulation of acetylated histones at H3K9 and H4K5 in HCT-116 cells.

Apoptosis Analysis

Cell Line: HCT-116[1]
Concentration: 0.1, 0.5, 1, 5 and 10 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis in HCT-116 cells by 35.22%, 58.34, 80.7% at 0.5, 1, 5 μM, mainly occurring in early apoptosis.

Cell Cycle Analysis

Cell Line: HCT-116[1]
Concentration: 0.1, 0.5, 1, 5 and 10 μM
Incubation Time: 0, 6, 12 and 24 hours
Result: Caused G0/G1 phase arrest of HCT-116 cells in a time-dependent manner, effectively preventing cell cycle progression.
分子量

449.94

Formula

C23H24ClN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-37 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-372766466-56-0HDACApoptosisHistone deacetylasesHistone deacetylaseAntiproliferativeCell cycleCancerHCT-116 cellsInhibitorinhibitorinhibit

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目录号：
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