2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. SAHA-OH

SAHA-OH 是一种选择性的 HDAC6 抑制剂 (IC50=23 nM)，与 HDAC1、2、3 和 8 相比，其对 HDAC6 有 10-47 倍的选择性。SAHA-OH 具有抗炎活性，并可减少巨噬细胞的凋亡。

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SAHA-OH Chemical Structure

SAHA-OH Chemical Structure

CAS No. : 2857098-30-5

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SAHA-OH 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis[1].

IC50 & Target[1]

HDAC6

23 nM (IC50)

HDAC1

237 nM (IC50)

HDAC3

359 nM (IC50)

HDAC2

399 nM (IC50)

HDAC8

1070 nM (IC50)

体外研究
(In Vitro)

SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages[1].
SAHA-OH (0.01 μM; 3 h) treatment in BMMØs (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions[1].
SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAHA-OH 相关抗体:

Cell Viability Assay[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 0.67-10.76 μM
Incubation Time: 51 h
Result: Showed IC50 value in unstimulated BMMØs of 1.26 μM, and showed IC50 value in LPS-stimulated BMMØs of 10.76 μM.

Apoptosis Analysis[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 0-30 μM
Incubation Time: 3 h
Result: Resulted in a 24- to 26-fold increase in cellular viability as compared to the SAHA treatment.

Cell Cytotoxicity Assay[1]

Cell Line: B cells
Concentration: 0-30 μM
Incubation Time: 3 h
Result: Resulted in a 5-fold enhancement in viability and a 3-fold decrease in cell death for the B cell population.

Western Blot Analysis[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 10 μM
Incubation Time: 4 or 9 h
Result: Resulted in the acetylation of α-tubulin.
Induced the acetylation of histone H3 compared to no treatment (NT).
体内研究
(In Vivo)

SAHA-OH (intraperitoneal injection; 50 mg/kg; once) treatment prevents splenic organ damage, and reduces plasma proinflammatory cytokine levels in LPS-induced endotoxemia mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced endotoxemia mouse model[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50 mg/kg; once
Result: Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.
Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
分子量

294.35

Formula

C15H22N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAHA-OH 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAHA-OH2857098-30-5HDACApoptosisHistone deacetylasesanti-inflammatory activityBMM?sbone marrow macrophagesB cellInhibitorinhibitorinhibit

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HY-151569
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