2. PROTAC Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PROTACs HDAC Apoptosis
  4. YX968

YX968 是一种有效选择性的 HDAC3/8 PROTAC 双降解剂，DC50 值为 1.7 和 6.8 nM。YX968 通过促进细胞凋亡 (apoptosis) 发挥抗肿瘤活性。(Pink: Target protein ligand (HY-168287); Black: linker (HY-W007700); Blue: E3 ligase ligand (HY-112078))

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YX968 Chemical Structure

YX968 Chemical Structure

CAS No. : 2742732-92-7

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YX968 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YX968 is a potent and selective HDAC3/8 PROTAC dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1].(Pink: Target protein ligand (HY-168287); Black: linker (HY-W007700); Blue: E3 ligase ligand (HY-112078))

IC50 & Target

HDAC3

1.7 nM (DC50)

HDAC8

6.8 nM (DC50)

体外研究
(In Vitro)

YX968 (1 μM, 24 h) 可通过阻滞细胞 G1 期诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YX968 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0.063, 0.25, 1, 4, 16, 64 μM
Incubation Time: 16 h
Result: CASP3 cleavage (activation) was induced by YX968 in a dose-dependent manner.
分子量

831.12

Formula

C45H66N8O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YX968 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YX9682742732-92-7YX 968YX-968PROTACsHDACApoptosisHistone deacetylasesDegraderMDA-MB-231Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-164233
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