AKAP8 - A-kinase anchoring protein 8 Gene

中文名称：A-激酶锚定蛋白 8

种属: Homo sapiens

同用名: AKAP-8; AKAP95; AKAP 95; AKAP-95

关于 AKAP8

功能概要

该基因编码 A 激酶锚定蛋白家族的一个成员。 A-激酶锚定蛋白是支架蛋白，包含蛋白激酶 A (PKA) 的 RI/RII 亚基的结合结构域，并将 PKA 和其他信号分子募集到特定的亚细胞位置。该基因编码一种核 A 激酶锚定蛋白，该蛋白与 PKA 的 RII α 亚基结合，并可能通过将 PKA 和凝聚蛋白复合物靶向染色质在有丝分裂期间的染色体浓缩中发挥作用。该基因的假基因位于 9 号染色体的短臂上。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]