MYCBP - MYC binding protein Gene

中文名称：MYC 结合蛋白

种属: Homo sapiens

同用名: AMY-1

关于 MYCBP

功能概要

该基因编码的蛋白质与致癌蛋白 c-Myc 的 N 端结合，增强 c-Myc 激活 E 盒依赖性转录的能力。编码的蛋白质通常存在于细胞质中，但它在细胞周期的 S 期转移到细胞核并与 c-Myc 结合。这种蛋白质可能参与精子发生。该基因可被 microRNA-22 沉默。已发现该基因的两种转录变体，一种编码蛋白质，另一种可能不编码蛋白质。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene binds to the N-terminus of the oncogenic protein c-Myc, enhancing the ability of c-Myc to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with c-Myc. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the Other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]