2. Gene
  3. PRKAR2A - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

PRKAR2A - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 cAMP 依赖性 II 型调节亚基 α

种属: Homo sapiens

同用名: PKR2; PRKAR2

基因 ID: 5576 | 基因类型: protein coding

关于 PRKAR2A

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,744,591-48,847,874 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.3), colon (RPKM 10.8) and 25 other tissues.

功能概要

cAMP 是一种对多种细胞功能很重要的信号分子。 cAMP 通过激活依赖于 cAMP 的蛋白激酶发挥作用，后者通过不同靶蛋白的磷酸化来转导信号。无活性激酶全酶是由两个调节亚基和两个催化亚基组成的四聚体。 cAMP 导致非活性全酶解离成与四个 cAMP 和两个游离单体催化亚基结合的调节亚基二聚体。已在人类中鉴定出四种不同的调节亚基和三种催化亚基。该基因编码的蛋白质是调节亚基之一。该亚基可被活化的催化亚基磷酸化。它可能与各种 A 激酶锚定蛋白相互作用，并决定 cAMP 依赖性蛋白激酶的亚细胞定位。该亚基已被证明可以调节蛋白质从核内体到高尔基体并进一步到内质网 (ER) 的运输。[RefSeq 提供，2008 年 7 月]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

PRKAR2A 基因产物(4)

mRNA Protein Name
NM_001321982.2 NP_001308911.1 cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a
NM_001321983.2 NP_001308912.1 cAMP-dependent protein kinase type II-alpha regulatory subunit isoform b
NM_001321989.2 NP_001308918.1 cAMP-dependent protein kinase type II-alpha regulatory subunit isoform c
NM_004157.4 NP_004148.1 cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP-dependent protein kinase inhibitor activity IDA
IDA: 通过直接分析推断
21812984 GOA
enables cAMP-dependent protein kinase regulator activity IDA
IDA: 通过直接分析推断
21812984 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9473338 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
25097019 GOA
enables protein kinase A catalytic subunit binding IPI
IPI: 通过物理相互作用推断
17911601 GOA
enables ubiquitin protein ligase binding IDA
IDA: 通过直接分析推断
21423175 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: 通过直接分析推断
21812984 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with axoneme IDA
IDA: 通过直接分析推断
12475942 GOA
part of cAMP-dependent protein kinase complex IDA
IDA: 通过直接分析推断
12475942 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21423175 GOA
part of nucleotide-activated protein kinase complex IDA
IDA: 通过直接分析推断
21812984 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21423175 GOA
located in plasma membrane raft IDA
IDA: 通过直接分析推断
17911601 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
25097019 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKAR2A 蛋白结构

RIIa

RIIa: Regulatory subunit of type II PKA R-subunit (9 - 45)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (158 - 244)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (280 - 372)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
蛋白主名 其他名称

cAMP-dependent protein kinase type II-alpha regulatory subunit

cAMP-dependent protein kinase regulatory subunit RII alpha

PRKAR2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRKAR2A P13861 AKAP1 Homo sapiens Q92667
Anti Bait CoIP
24083380
种属内
PRKAR2A P13861 AKAP3 Homo sapiens O75969
Pull Down
11278869
种属间: 跨种属相互作用 种属内: 同种属相互作用

PRKAR2A 抗体

目录号 产品名 应用 反应物种
HY-P80847 Phospho-PKA RII alpha (Ser99) Antibody WB, IHC-P, ICC/IF, IP Human, Mouse, Rat, Pig

关联疾病

疾病名称 别名
Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome

NNMS

Chondrodysplasia-Disorder Of Sex Development Syndrome

Nivelon Nivelon Mabille Syndrome
Carney Complex Variant

Carney Complex

Carney Syndrome

Carney Complex, Type 1

Lamb Syndrome

Name Syndrome

Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome

Carney Complex - Trismus - Pseudocamptodactyly Syndrome

Carney Complex, Type 2

Car

Cnc1

Carney Myxoma-Endocrine Complex

Myxoma - Spotty Pigmentation - Endocrine Overactivity

Myxoma, Spotty Pigmentation, And Endocrine Overactivity

Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome

Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome

Carney Complex-Trismus-Pseudocamptodactyly Syndrome

CACOV
Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma

Fhcc

Fibrolamellar Hepatocarcinoma

Hepatocellular Carcinoma, Fibrolamellar

Oncocytic Hepatocellular Tumor

Eosinophilic Glassy Cell Hepatoma

Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis

Fl-Hcc

Fibrolamellar Oncocytic Hepatoma

Hepatocellular Carcinoma With Increased Stromal Fibrosis

Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Primary Pigmented Nodular Adrenocortical Disease

Ppnad

Primary Pigmented Nodular Adrenal Dysplasia

Pigmented Nodular Adrenocortical Disease, Primary, 2

Pigmented Nodular Adrenocortical Disease, Primary, 1
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11114 PRKAR2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PRKAR2A VGNC VGNC:76407
Mus musculus PRKAR2A MGD MGI:108025
Rattus norvegicus PRKAR2A RGD RGD:3393
Felis catus PRKAR2A VGNC VGNC:69053
Canis familiaris PRKAR2A VGNC VGNC:44976
Bos taurus PRKAR2A VGNC VGNC:33325
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