SUZ12 - SUZ12 polycomb repressive complex 2 subunit Gene

中文名称：SUZ12 多梳抑制复合体 2 亚基

种属: Homo sapiens

同用名: CHET9; IMMAS; JJAZ1

基因 ID: 23512 | 基因类型: protein coding

关于 SUZ12

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,937,007-32,001,038 (from NCBI)

This gene has 4 transcripts (splice variants), 275 orthologues and is associated with 92 phenotypes. Ubiquitous expression in testis (RPKM 13.7), lymph node (RPKM 12.3) and 25 other tissues.

功能概要

这种锌指基因已在子宫内膜间质肉瘤中报道的复发性染色体易位的断点处被鉴定出来。这些断点的重组导致该基因与 JAZF1 融合。该基因编码的蛋白质在编码区的 C 末端含有一个锌指结构域。[RefSeq 提供，2009 年 7 月]

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

SUZ12 基因产物(2)

mRNA	Protein	Name
NM_001321207.2	NP_001308136.1	polycomb protein SUZ12 isoform 2
NM_015355.4	NP_056170.2	polycomb protein SUZ12 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme activator activity	IMP IMP: 通过突变表型推断	15385962	GOA
enables methylated histone binding	IDA IDA: 通过直接分析推断	21029866	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17560333	GOA
enables transcription corepressor binding	IPI IPI: 通过物理相互作用推断	29628311	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cell differentiation	IMP IMP: 通过突变表型推断	19847889	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ESC/E(Z) complex	IDA IDA: 通过直接分析推断	20075857	GOA
part of ESC/E(Z) complex	IMP IMP: 通过突变表型推断	15385962	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUZ12 蛋白结构

VEFS-Box

0
200
400
600
739 a.a.

蛋白主名

其他名称

polycomb protein SUZ12

chET 9 protein

SUZ12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SUZ12	Q15022	JARID2	Homo sapiens	Q92833-1	Anti Tag CoIP	20075857
种属内	SUZ12	Q15022	JARID2	Homo sapiens	Q92833-1	Anti Bait CoIP	20075857
种属内	SUZ12	Q15022	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	20075857
种属内	SUZ12	Q15022	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	23079660
种属内	SUZ12	Q15022	EZH2	Homo sapiens	Q15910	Anti Tag CoIP	20075857
种属内	SUZ12	Q15022	EZH2	Homo sapiens	Q15910	CH-IP	23238014
种属内	SUZ12	Q15022	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	22439931
种属内	SUZ12	Q15022	HDAC3	Homo sapiens	O15379	Anti Bait CoIP	23079660
种属内	SUZ12	Q15022	PML-RAR	Homo sapiens	Q15156	Anti Bait CoIP	17560333
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	Anti Bait CoIP	22439931
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	Anti Tag CoIP	35016035
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	Anti Tag CoIP	20075857
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	Anti Tag CoIP	20543829
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	TAP	24981860
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	TAP	27705803
种属内	SUZ12	Q15022	EED	Homo sapiens	O75530	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

SUZ12 抗体

目录号	产品名	应用	反应物种
HY-P83440	Polycomb Protein SUZ12 Antibody (YA3185)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Imagawa-Matsumoto Syndrome

IMMAS

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Acute Megakaryoblastic Leukemia In Down Syndrome

Ds-Amkl

Atypical Neurofibroma

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Plexiform Neurofibroma

Neurofibroma Plexiform

Neurofibroma, Plexiform

Endometrial Stromal Nodule

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Vaginal Endometrial Stromal Sarcoma

Vagina Sarcoma

Sarcoma Of The Vagina

Vaginal Sarcoma

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Childhood Malignant Schwannoma

Pediatric Mpnst

Childhood Neurofibrosarcoma

Cellular Leiomyoma

Adult Malignant Schwannoma

Adult Mpnst

Adult Neurofibrosarcoma

Epithelioid Malignant Peripheral Nerve Sheath Tumor

Epithelioid Mpnst

Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules	Ovarian Sex Cord-Stromal Tumor
Stromal Tumor Of Ovary

Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor

Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101512	A-395	Inhibitor	99.12%	否
HY-W014099	Boc-NH-C4-acid		99.85%	否
HY-157164	PROTAC EZH2 Degrader-2	Degrader	99.78%	否
HY-158239	MS181	Inhibitor	98.36%	否
HY-130638	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc		/	否
HY-130637	Boc-NH-PEG1-Ph-O-CH2COOH		/	否
HY-RS14053	SUZ12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SUZ12	VGNC	VGNC:65859
Bos taurus	SUZ12	VGNC	VGNC:35493
Macaca mulatta	SUZ12	VGNC	VGNC:78144
Mus musculus	SUZ12	MGD	MGI:1261758
Canis familiaris	SUZ12	VGNC	VGNC:47002
Rattus norvegicus	SUZ12	RGD	RGD:1593621

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