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  2. PPP4R1 - protein phosphatase 4 regulatory subunit 1 Gene

PPP4R1 - protein phosphatase 4 regulatory subunit 1 Gene

中文名称:蛋白磷酸酶 4 调节亚基 1

种属: Homo sapiens

同用名: MEG1; PP4R1; PP4(Rmeg)

基因 ID: 9989 | 基因类型: protein coding

关于 PPP4R1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,546,794-9,617,199 (from NCBI)

This gene has 29 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 39.0), testis (RPKM 25.5) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白磷酸酶 4 (PP4) 的几个替代调节亚基之一。该蛋白质具有多个 HEAT 重复序列。该蛋白质与 PP4RC 形成复合物。该复合体可能具有与其他 PP4 复合体不同的作用,包括 HDAC3 的调节 (Zhang 等人,PMID:15805470) 。 20 号染色体上还有一个转录的假基因。可变剪接导致多个转录变体。[RefSeq 提供,2012 年 6 月]

This gene encodes one of several alternate regulatory subunits of serine/threonine protein Phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from Other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PPP4R1 基因产物(3)

mRNA Protein Name
NM_001042388.3 NP_001035847.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a
NM_001382562.1 NP_001369491.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform c
NM_005134.4 NP_005125.1 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

PPP4R1 蛋白结构

HEAT

HEAT: HEAT repeat (253 - 279)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 950 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 4 regulatory subunit 1

serine/threonine phosphatase 4

PPP4R1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Bait CoIP
18614045
种属内
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Tag CoIP
26496610
种属内
PPP4R1 Q8TF05 PPP4C Homo sapiens P60510
Anti Tag CoIP
18715871
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPP4R1 VGNC VGNC:33269
Macaca mulatta PPP4R1 VGNC VGNC:104233
Felis catus PPP4R1 VGNC VGNC:69023
Rattus norvegicus PPP4R1 RGD RGD:619798
Canis familiaris PPP4R1 VGNC VGNC:53875
Mus musculus PPP4R1 MGD MGI:1917601