PPP4R2 - protein phosphatase 4 regulatory subunit 2 Gene

中文名称：蛋白磷酸酶 4 调节亚基 2

种属: Homo sapiens

同用名: PP4R2

基因 ID: 151987 | 基因类型: protein coding

关于 PPP4R2

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,996,743-73,069,198 (from NCBI)

This gene has 7 transcripts (splice variants) and 93 orthologues. Ubiquitous expression in bone marrow (RPKM 21.8), testis (RPKM 13.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸-蛋白磷酸酶 4 复合物的调节亚基。除了需要有效的 DNA 双链断裂修复外，该复合物还在中心体微管的组织和剪接体 snRNP 的加工中发挥作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein Phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PPP4R2 基因产物(5)

mRNA	Protein	Name
NM_001318025.2	NP_001304954.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 2
NM_001318026.2	NP_001304955.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 3
NM_001318027.2	NP_001304956.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 4
NM_001318028.2	NP_001304957.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 5
NM_174907.4	NP_777567.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16085932	GOA
enables protein phosphatase regulator activity	IMP IMP: 通过突变表型推断	20154705	GOA
enables protein-macromolecule adaptor activity	IMP IMP: 通过突变表型推断	20154705	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of double-strand break repair	IMP IMP: 通过突变表型推断	18614045	GOA
involved in regulation of double-strand break repair via homologous recombination	IMP IMP: 通过突变表型推断	20154705	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	18614045	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20154705	GOA
part of protein phosphatase 4 complex	IDA IDA: 通过直接分析推断	20154705	GOA
part of protein phosphatase 4 complex	IPI IPI: 通过物理相互作用推断	18614045	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP4R2 蛋白结构

PPP4R2

0
100
200
300
361 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 4 regulatory subunit 2

PPP4R2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	28514442
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Bait CoIP	18614045
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	33961781
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	BioID	28330616
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	26496610
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	18715871
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	TAP	16085932
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Pull Down	28330616
种属内	PPP4R2	Q9NY27	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	16085932
种属内	PPP4R2	Q9NY27	PTPA	Homo sapiens	Q15257	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Basal Cell Carcinoma, Infundibulocystic

Basal Cell Carcinoma With Follicular Differentiation	Infundibulocystic Basal Cell Carcinoma
Skin Infundibulocystic Basal Cell Carcinoma

Eccrine Papillary Adenocarcinoma

Digital Papillary Adenocarcinoma	Sweat Gland Adenocarcinoma
Digital Papillary Eccrine Carcinoma Of Skin

Malignant Acrospiroma

Eccrine Ductal Carcinoma	Hidradenocarcinoma
Anaplastic Syringoma	Eccrine Ductal Carcinoma Of Skin
Clear Cell Eccrine Carcinoma	Malignant Clear Cell Acrospiroma
Malignant Nodular/Clear Cell Hidradenoma	Primary Mucoepidermoid Cutaneous Carcinoma
Sweat Gland Adenocarcinoma

Eccrine Adenocarcinoma

Ulceroglandular Tularemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11030	PPP4R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PPP4R2	VGNC	VGNC:110347
Rattus norvegicus	PPP4R2	RGD	RGD:1307312
Canis familiaris	PPP4R2	VGNC	VGNC:44922
Bos taurus	PPP4R2	VGNC	VGNC:33270
Mus musculus	PPP4R2	MGD	MGI:3027896
Felis catus	PPP4R2	VGNC	VGNC:64328

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP4R2 - protein phosphatase 4 regulatory subunit 2 Gene

关于 PPP4R2

功能概要

PPP4R2 基因产物(5)

PPP4R2 蛋白结构

PPP4R2 蛋白互作信息

关联疾病

直系同源

热门区域

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PPP4R2 - protein phosphatase 4 regulatory subunit 2 Gene

关于 PPP4R2

功能概要

PPP4R2 基因产物(5)

PPP4R2 蛋白结构

PPP4R2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z