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  2. PTPA - protein phosphatase 2 phosphatase activator Gene

PTPA - protein phosphatase 2 phosphatase activator Gene

中文名称:蛋白磷酸酶 2 磷酸酶激活因子

种属: Homo sapiens

同用名: PP2A; PR53; PPP2R4

基因 ID: 5524 | 基因类型: protein coding

关于 PTPA

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,110,950-129,148,946 (from NCBI)

This gene has 24 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 35.1), brain (RPKM 26.2) and 25 other tissues.

功能概要

蛋白磷酸酶 2A 是四种主要的 Ser/Thr 磷酸酶之一,与细胞生长和分裂的负调控有关。蛋白磷酸酶 2A 全酶是由结构亚基 A、催化亚基 C 和调节亚基 B 组成的异源三聚体蛋白。调节亚基由一组不同的基因编码,这些基因已分为 B/PR55、B'/PR61 和 B''/PR72 家族。这些不同的调节亚基赋予全酶不同的酶特异性和细胞内定位。该基因的产物属于 B'家族。该基因编码蛋白磷酸酶 2A 的二聚体形式的特定磷酸酪氨酰磷酸酶激活剂。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl Phosphatase activator of the dimeric form of protein Phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PTPA 基因产物(6)

mRNA Protein Name
NM_001193397.2 NP_001180326.1 serine/threonine-protein phosphatase 2A activator isoform e
NM_001271832.2 NP_001258761.1 serine/threonine-protein phosphatase 2A activator isoform f
NM_021131.5 NP_066954.2 serine/threonine-protein phosphatase 2A activator isoform b
NM_178000.3 NP_821067.1 serine/threonine-protein phosphatase 2A activator isoform b
NM_178001.3 NP_821068.1 serine/threonine-protein phosphatase 2A activator isoform a
NM_178003.3 NP_821070.1 serine/threonine-protein phosphatase 2A activator isoform d
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16916641 GOA
enables phosphatase binding IDA
IDA: 通过直接分析推断
16916641 GOA
contributes to phosphoprotein phosphatase activity IDA
IDA: 通过直接分析推断
16916641 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16916641 GOA
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
16916641 GOA
enables protein phosphatase regulator activity IDA
IDA: 通过直接分析推断
16916641 GOA
enables protein tyrosine phosphatase activator activity IDA
IDA: 通过直接分析推断
16916641 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
10830164 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
17333320 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ATPase complex IDA
IDA: 通过直接分析推断
16916641 GOA
part of calcium channel complex IDA
IDA: 通过直接分析推断
10830164 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17333320 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17333320 GOA
part of protein phosphatase type 2A complex IDA
IDA: 通过直接分析推断
10318862 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTPA 蛋白结构

PTPA

PTPA: Phosphotyrosyl phosphate activator (PTPA) protein (26 - 355)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A activator

PP2A phosphatase activator

PTPA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPA Q15257 PPP4C Homo sapiens P60510
Anti Tag CoIP
33961781
种属内
PTPA Q15257 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia

Acute Leukemia Of Ambiguous Lineage

Acute Undifferentiated Leukemia

Acute Leukemia Of Indeterminate Lineage

Hybrid Acute Leukemia

Mixed Lineage Acute Leukemia

All With Myeloid Markers

Aml With Lymphoid Markers

Acute Leukemia Of Undetermined Lineage

Bal

Biphenotypic Acute Leukemia

Undifferentiated Acute Leukemia

Mpal

Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

Leukemia, Biphenotypic, Acute

Chromosome 13q14 Deletion Syndrome

Chromosome 13q Deletion Syndrome

Deletion 13q14

Chromosome 13q Deletion

13q Deletion

13q Monosomy

Deletion 13q

Monosomy 13q

Monosomy 13q14

Del(13)(Q14)

Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PTPA VGNC VGNC:76583
Canis familiaris PTPA VGNC VGNC:45164
Felis catus PTPA VGNC VGNC:97576
Bos taurus PTPA VGNC VGNC:33526
Mus musculus PTPA MGD MGI:1346006
Rattus norvegicus PTPA RGD RGD:1308354
Others PTPA NCBI