2. Gene
  3. RNF14 - ring finger protein 14 Gene

RNF14 - ring finger protein 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 14

种属: Homo sapiens

同用名: ARA54; HFB30; TRIAD2; HRIHFB2038

基因 ID: 9604 | 基因类型: protein coding

关于 RNF14

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,949,337-141,990,292 (from NCBI)

This gene has 16 transcripts (splice variants), 285 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质包含一个 RING 锌指，这是一种已知参与蛋白质-蛋白质相互作用的基序。这种蛋白质与雄激素受体 (AR) 相互作用，可能作为共激活因子在前列腺中诱导 AR 靶基因表达。该基因的显性失活突变体已被证明可抑制 AR 介导的前列腺癌生长。该蛋白还与 III 类泛素结合酶 (E2) 相互作用，并可在某些核蛋白的泛素化过程中充当泛素连接酶 (E3) 。已经报道了编码两种不同亚型的六种选择性剪接的转录本变体。[RefSeq 提供，2011 年 1 月]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with Androgen Receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate Cancer. This protein also interacts with class III ubiquitin-conjugating Enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

RNF14 基因产物(6)

mRNA Protein Name
NM_001201365.2 NP_001188294.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_004290.5 NP_004281.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183398.3 NP_899645.1 E3 ubiquitin-protein ligase RNF14 isoform 2
NM_183399.3 NP_899646.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183400.3 NP_899647.1 E3 ubiquitin-protein ligase RNF14 isoform 1
NM_183401.3 NP_899648.1 E3 ubiquitin-protein ligase RNF14 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
19345326 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10085091 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
27863242 GOA
enables ubiquitin-like protein transferase activity IDA
IDA: 通过直接分析推断
11322894 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19345326 GOA
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
27863242 GOA
involved in protein ubiquitination IEP
IEP: 通过表达模式推断
11322894 GOA
involved in protein-RNA covalent cross-linking repair IDA
IDA: 通过直接分析推断
37951215 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
19345326 GOA
involved in regulation of androgen receptor signaling pathway IDA
IDA: 通过直接分析推断
19345326 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
23449499 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
27863242 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27863242 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11322894 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
27863242 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11322894 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF14 蛋白结构

RWD

RWD: RWD domain (4 - 133)

IBR

IBR: IBR domain, a half RING-finger domain (290 - 350)

IBR

IBR: IBR domain, a half RING-finger domain (381 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF14

androgen receptor associated protein 54

RNF14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF14 Q9UBS8 DACH1 Homo sapiens Q9UI36-2
Validated Y2H
32296183
种属内
RNF14 Q9UBS8 AR Homo sapiens P10275
Anti Bait CoIP
19345326
种属内
RNF14 Q9UBS8 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
种属内
RNF14 Q9UBS8 UBE2D1 Homo sapiens P51668
Validated Y2H
25416956
种属内
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
25416956
种属内
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Y2H Prey Pooling
25416956
种属内
RNF14 Q9UBS8 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

RNF14 抗体

目录号 产品名 应用 反应物种
HY-P83471 RNF14 Antibody (YA3216) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Microcephaly With Spastic Quadriplegia

Recessive Microcephaly With Spastic Quadriplegia
Diencephalic-Mesencephalic Junction Dysplasia Syndrome 1

DMJDS1

Microcephaly, Seizures, Spasticity, And Brain Calcifications

Missbc

Microcephaly With Spastic Quadriplegia

Dysplasia, Diencephalic-Mesencephalic Junction, Syndrome 1
Diencephalic-Mesencephalic Junction Dysplasia

Diencephalic-Mesencephalic Junction Dysplasia Syndrome
Coats Disease

Exudative Retinopathy

Retinal Telangiectasis

Coats' Disease

Leber Miliary Aneurysm

Coats' Syndrome

Congenital Retinal Telangiectasia
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12052 RNF14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNF14 MGD MGI:1929668
Felis catus RNF14 VGNC VGNC:64671
Rattus norvegicus RNF14 RGD RGD:1589576
Canis familiaris RNF14 VGNC VGNC:45633
Bos taurus RNF14 VGNC VGNC:34024
Macaca mulatta RNF14 VGNC VGNC:84488
Others RNF14 NCBI
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