MPND - MPN domain containing Gene

中文名称：含 MPN 域

种属: Homo sapiens

基因 ID: 84954 | 基因类型: protein coding

关于 MPND

This gene has 8 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 12.4), duodenum (RPKM 11.4) and 25 other tissues.

功能概要

预测启用组蛋白结合活性；肽酶活性；和转录共激活因子活性。预测参与染色质重塑和 RNA 聚合酶 II 对转录的正调控。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable histone binding activity; peptidase activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

MPND 基因产物(3)

mRNA	Protein	Name
NM_001159846.3	NP_001153318.1	MPN domain-containing protein isoform 2
NM_001300862.2	NP_001287791.1	MPN domain-containing protein isoform 3
NM_032868.6	NP_116257.2	MPN domain-containing protein isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MPND 蛋白结构

JAB

0
100
200
300
400
471 a.a.

蛋白主名

其他名称

MPN domain-containing protein

MPND 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
种属内	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
种属内	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
种属内	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	MPND	Q8N594	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	MPND	Q8N594	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	MPND	Q8N594	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis	Familial Amyloid Polyneuropathy
Ttr Amyloid Neuropathy	Transthyretin Amyloid Neuropathy
Transthyretin Amyloid Polyneuropathy	Fap
Familial Transthyretin Amyloidosis	Amyloidosis Transthyretin Related
Type I Familial Amyloid Polyneuropathy	Familial Amyloid Polyneuropathy Type I
Attrv122i Amyloidosis	Hereditary Amyloidosis, Transthyretin-Related
Amyloid Polyneuropathy, Familial	Attr Amyloidosis
Attrm Amyloidosis	Corino De Andrade'S Disease
Paramyloidosis	Transthyretin-Related Hereditary Amyloidosis
Ttr Amyloidosis	Hereditary Attr Amyloidosis
Portuguese Polyneuritic Amyloidosis	Portuguese Type Familial Amyloid Neuropathy
Swiss Type Amyloid Polyneuropathy	Type Ii Familial Amyloid Polyneuropathy
Attrv30m Amyloidosis	Attrv30m-Related Amyloidosis
Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type	Attr Cardiomyopathy
Attrv122i-Related Amyloidosis	Ttr-Related Amyloid Cardiomyopathy
Ttr-Related Cardiac Amyloidosis	Transthyretin Amyloid Cardiopathy
Transthyretin-Related Familial Amyloid Cardiomyopathy	Amyloidosis, Transthyretin-Related
AMYL-TTR	Amyloidosis I
Amyloidosis Ohio Type	Amyloidosis Type 7
Amyloidosis Vii	Amyloid Polyneuropathy
Attr	Familial Amyloid Polyneuropathy Type Ii
Hereditary Amyloidosis Transthyretin-Related	Leptomeningeal Amyloidosis
Meningocerebrovascular Amyloidosis	Oculoleptomeningeal Amyloidosis
Familial Amyloid Polyneuropathies	Amyloidosis, Leptomeningeal
Senile Cardiac Amyloidosis	Amyloid Neuropathies, Familial
Danish Type Familial Amyloid Cardiomyopathy	Familial Amyloid Neuropathy, Portuguese Type
Amyloid Polyneuropathy, Swiss Type	Hereditary Oculoleptomeningeal Amyloid Angiopathy
Amyloid Neuropathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08620	MPND Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MPND	VGNC	VGNC:31580
Canis familiaris	MPND	VGNC	VGNC:43340
Felis catus	MPND	VGNC	VGNC:63573
Macaca mulatta	MPND	VGNC	VGNC:74831
Rattus norvegicus	MPND	RGD	RGD:1589335
Mus musculus	MPND	MGD	MGI:1915297
Others	MPND	NCBI

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