QARS1 - glutaminyl-tRNA synthetase 1 Gene

种属: Homo sapiens (human)

同用名: QARS; GLNRS; MSCCA; PRO2195

关于 QARS1

功能概要

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other Amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I Aminoacyl-tRNA Synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]