1. Gene
  2. SPRED2 - sprouty related EVH1 domain containing 2 Gene

SPRED2 - sprouty related EVH1 domain containing 2 Gene

中文名称:含萌发蛋白相关的 EVH1 域 2

种属: Homo sapiens

同用名: NS14; Spred-2

基因 ID: 200734 | 基因类型: protein coding

关于 SPRED2

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,307,175-65,432,599 (from NCBI)

This gene has 8 transcripts (splice variants), 278 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues.

功能概要

SPRED2 是 Sprouty (参见 SPRY1;MIM 602465) /SPRED 蛋白家族的成员,可调节生长因子诱导的 MAP 激酶级联激活 (参见 MAPK1;MIM 176948) (Nonami 等人,2004 [PubMed 15465815]) .[OMIM 提供,2008 年 3 月]

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

SPRED2 基因产物(2)

mRNA Protein Name
NM_001128210.2 NP_001121682.1 sprouty-related, EVH1 domain-containing protein 2 isoform b
NM_181784.3 NP_861449.2 sprouty-related, EVH1 domain-containing protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19822672 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20736167 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
20736167 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPRED2 蛋白结构

WH1

WH1: WH1 domain (14 - 118)

Sprouty

Sprouty: Sprouty protein (Spry) (306 - 411)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
蛋白主名 其他名称

sprouty-related, EVH1 domain-containing protein 2

sprouty protein with EVH-1 domain 2, related sequence

SPRED2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SPRED2 Q7Z698 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra SPRED2 Q7Z698 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812
Validated Y2H
32814053
Intra SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812
Y2H Array
32814053
Intra SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812
Anti Tag CoIP
28514442
Intra SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra SPRED2 Q7Z698 LCE2B Homo sapiens O14633
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 LCE2B Homo sapiens O14633
Y2H Array
32296183
Intra SPRED2 Q7Z698 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra SPRED2 Q7Z698 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3
Y2H Array
32296183
Intra SPRED2 Q7Z698 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra SPRED2 Q7Z698 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra SPRED2 Q7Z698 ZNF575 Homo sapiens Q86XF7
Validated Y2H
32296183
Intra SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 TSNAX Homo sapiens Q99598
Validated Y2H
32296183
Intra SPRED2 Q7Z698 TSNAX Homo sapiens Q99598
Y2H Array
32296183
Intra SPRED2 Q7Z698 TSNAX Homo sapiens Q99598
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2
Validated Y2H
32296183
Intra SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Array
32296183
Intra SPRED2 Q7Z698 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra SPRED2 Q7Z698 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra SPRED2 Q7Z698 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra SPRED2 Q7Z698 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra SPRED2 Q7Z698 TOP3B Homo sapiens O95985
Y2H Prey Pooling
25416956
Intra SPRED2 Q7Z698 TOP3B Homo sapiens O95985
Y2H Array
29892012
Intra SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 RBM48 Homo sapiens Q5RL73
Y2H Array
32296183
Intra SPRED2 Q7Z698 RBM48 Homo sapiens Q5RL73
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5
Anti Tag CoIP
33961781
Intra SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SPRED2 Q7Z698 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SPRED2 Q7Z698 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 RPS6KA6 Homo sapiens Q9UK32
Validated Y2H
32296183
Intra SPRED2 Q7Z698 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra SPRED2 Q7Z698 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra SPRED2 Q7Z698 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra SPRED2 Q7Z698 VSNL1 Homo sapiens P62760
Y2H Array
32296183
Intra SPRED2 Q7Z698 VSNL1 Homo sapiens P62760
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Y2H Array
31515488
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Validated Y2H
25416956
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Y2H Array
25416956
Intra SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
Intra SPRED2 Q7Z698 ZNF414 Homo sapiens Q96IQ9
Validated Y2H
32296183
Intra SPRED2 Q7Z698 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra SPRED2 Q7Z698 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra SPRED2 Q7Z698 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra SPRED2 Q7Z698 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra SPRED2 Q7Z698 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra SPRED2 Q7Z698 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Noonan Syndrome 14

NS14

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Pseudo-Turner Syndrome

Noonan Syndrome

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SPRED2 VGNC VGNC:106225
Canis familiaris SPRED2 VGNC VGNC:46763
Bos taurus SPRED2 VGNC VGNC:58416
Mus musculus SPRED2 MGD MGI:2150019
Rattus norvegicus SPRED2 RGD RGD:1309304
Felis catus SPRED2 VGNC VGNC:65647