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  2. RPS6KA6 - ribosomal protein S6 kinase A6 Gene

RPS6KA6 - ribosomal protein S6 kinase A6 Gene

中文名称:核糖体蛋白 S6 激酶 A6

种属: Homo sapiens

同用名: RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6

基因 ID: 27330 | 基因类型: protein coding

关于 RPS6KA6

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:84,058,346-84,188,499 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 7 paralogues. Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues.

功能概要

该基因编码核糖体 S6 激酶家族成员,即受生长因子调节的丝氨酸-苏氨酸蛋白激酶。然而,所编码的蛋白质可能不同于该家族的其他成员,因为研究表明它不依赖于生长因子并且可能不参与相同的信号通路。[RefSeq 提供,2010 年 1 月]

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

RPS6KA6 基因产物(10)

mRNA Protein Name
XM_017029424.2 XP_016884913.1 ribosomal protein S6 kinase alpha-6 isoform X1
XM_011530919.3 XP_011529221.1 ribosomal protein S6 kinase alpha-6 isoform X4
XM_011530920.3 XP_011529222.1 ribosomal protein S6 kinase alpha-6 isoform X5
XM_011530917.3 XP_011529219.1 ribosomal protein S6 kinase alpha-6 isoform X2
XM_017029423.2 XP_016884912.1 ribosomal protein S6 kinase alpha-6 isoform X1
NM_001330512.1 NP_001317441.1 ribosomal protein S6 kinase alpha-6 isoform 1
XM_047441997.1 XP_047297953.1 ribosomal protein S6 kinase alpha-6 isoform X3
XM_017029425.2 XP_016884914.1 ribosomal protein S6 kinase alpha-6 isoform X1
NM_014496.5 NP_055311.1 ribosomal protein S6 kinase alpha-6 isoform 2
XM_047441996.1 XP_047297952.1 ribosomal protein S6 kinase alpha-6 isoform X3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: 通过突变表型推断
15042092 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPS6KA6 蛋白结构

Pkinase

Pkinase: Protein kinase domain (73 - 330)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (354 - 393)

Pkinase

Pkinase: Protein kinase domain (426 - 683)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-6

90 kDa ribosomal protein S6 kinase 6

S6K-alpha 6

p90-RSK 6

ribosomal S6 kinase 4

ribosomal protein S6 kinase, 90kDa, polypeptide 6

RPS6KA6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPS6KA6 Q9UK32 SPRED2 Homo sapiens Q7Z698
Y2H Array
32296183
Intra RPS6KA6 Q9UK32 SPRED2 Homo sapiens Q7Z698
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
X-Linked Nonsyndromic Deafness

X-Linked Deafness

Deafness, X-Linked

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome

Non-Syndromic X-Linked Intellectual Disability 77

Mrx77

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPS6KA6 VGNC VGNC:34145
Macaca mulatta RPS6KA6 VGNC VGNC:76932
Mus musculus RPS6KA6 MGD MGI:1914321
Rattus norvegicus RPS6KA6 RGD RGD:1560817
Canis familiaris RPS6KA6 VGNC VGNC:45743
Felis catus RPS6KA6 VGNC VGNC:64759
Others RPS6KA6 NCBI