KLC3 - kinesin light chain 3 Gene

中文名称：驱动蛋白轻链 3

种属: Homo sapiens

同用名: KLC2; KLCt; KLC2L; KNS2B

基因 ID: 147700 | 基因类型: protein coding

关于 KLC3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,340,750-45,351,519 (from NCBI)

This gene has 7 transcripts (splice variants), 373 orthologues and 5 paralogues. Biased expression in skin (RPKM 20.7), esophagus (RPKM 4.3) and 4 other tissues.

功能概要

该基因编码驱动蛋白轻链基因家族的成员。驱动蛋白是参与沿微管运输货物的分子马达，由两个驱动蛋白重链 (KHC) 和两个驱动蛋白轻链 (KLC) 分子组成。 KLC 被认为通常参与结合货物和调节驱动蛋白活性。在大鼠体内，一种类似于该基因产物的蛋白质在减数分裂后的精子细胞中表达，它与精子尾巴和线粒体的结构成分相关。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two Kinesin heavy chain (KHC) and two Kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating Kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

KLC3 基因产物(1)

mRNA	Protein	Name
NM_177417.3	NP_803136.2	kinesin light chain 3

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLC3 蛋白结构

Rab5-bind

TPR_1

TPR_12

TPR_10

0
100
200
300
400
504 a.a.

蛋白主名

其他名称

kinesin light chain 3

kinesin light chain 2

KLC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KLC3	Q6P597	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
种属内	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Y2H Array	31515488
种属内	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Validated Y2H	25416956
种属内	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Y2H Array	25416956
种属内	KLC3	Q6P597	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	25416956
种属内	KLC3	Q6P597	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
种属内	KLC3	Q6P597	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
种属内	KLC3	Q6P597	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
种属内	KLC3	Q6P597	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
种属内	KLC3	Q6P597	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	QARS1	Homo sapiens	P47897-2	Y2H Array	25416956
种属内	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
种属内	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
种属内	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
种属内	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	25416956
种属内	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Y2H Array	25416956
种属内	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
种属内	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Anti Tag CoIP	33961781
种属内	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Validated Y2H	25416956
种属内	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Y2H Array	25416956
种属内	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
种属内	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
种属内	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
种属内	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
种属内	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
种属内	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
种属内	KLC3	Q6P597	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
种属内	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
种属内	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
种属内	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
种属内	KLC3	Q6P597	BBS5	Homo sapiens	Q8N3I7	Y2H Array	25416956
种属内	KLC3	Q6P597	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	KLC3	Q6P597	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	KLC3	Q6P597	QARS1	Homo sapiens	P47897	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
种属内	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
种属内	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Y2H Array	32814053
种属内	KLC3	Q6P597	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
种属内	KLC3	Q6P597	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
种属内	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
种属内	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
种属内	KLC3	Q6P597	YWHAG	Homo sapiens	P61981	SLC	36931259
种属内	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	KLC3	Q6P597	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
种属内	KLC3	Q6P597	STX11	Homo sapiens	O75558	Validated Y2H	25416956
种属内	KLC3	Q6P597	STX11	Homo sapiens	O75558	Y2H Array	25416956
种属内	KLC3	Q6P597	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
种属内	KLC3	Q6P597	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
种属内	KLC3	Q6P597	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
种属内	KLC3	Q6P597	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
种属内	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
种属内	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
种属内	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Y2H Array	31515488
种属内	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Validated Y2H	25416956
种属内	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Y2H Array	25416956
种属内	KLC3	Q6P597	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Y2H Array	25416956
种属内	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	25416956
种属内	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Validated Y2H	25416956
种属内	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Y2H Array	25416956
种属内	KLC3	Q6P597	WAC	Homo sapiens	Q9BTA9	Y2H Prey Pooling	25416956
种属内	KLC3	Q6P597	WAC	Homo sapiens	Q9BTA9	Y2H Array	25416956
种属内	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
种属内	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
种属内	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Y2H Array	32814053
种属内	KLC3	Q6P597	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07328	KLC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	KLC3	MGD	MGI:1277971
Macaca mulatta	KLC3	VGNC	VGNC:73870
Canis familiaris	KLC3	VGNC	VGNC:42428
Felis catus	KLC3	VGNC	VGNC:63128
Rattus norvegicus	KLC3	RGD	RGD:621432
Bos taurus	KLC3	VGNC	VGNC:30624

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