WAC - WW domain containing adaptor with coiled-coil Gene

中文名称：含 WW 域和卷曲卷曲结构域的适配因子

种属: Homo sapiens

同用名: Wwp4; DESSH; BM-016; PRO1741

基因 ID: 51322 | 基因类型: protein coding

关于 WAC

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:28,532,779-28,623,112 (from NCBI)

This gene has 28 transcripts (splice variants), 292 orthologues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 29.5), thyroid (RPKM 26.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质包含一个 WW 结构域，这是一个广泛存在于信号蛋白中的蛋白质模块。该结构域介导蛋白质-蛋白质相互作用并结合含有富含脯氨酸或至少含有一种脯氨酸的短线性肽基序的蛋白质。该基因产物与小鼠 WAC 蛋白具有 94% 的序列同一性，但其确切功能尚不清楚。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 12 月]

The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

WAC 基因产物(3)

mRNA	Protein	Name
NM_016628.5	NP_057712.2	WW domain-containing adapter protein with coiled-coil isoform 1
NM_100264.3	NP_567822.1	WW domain-containing adapter protein with coiled-coil isoform 2
NM_100486.4	NP_567823.1	WW domain-containing adapter protein with coiled-coil isoform 3

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II complex binding	IDA IDA: 通过直接分析推断	21329877	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	21329877	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	21329877	GOA
involved in chromatin remodeling	IMP IMP: 通过突变表型推断	21329877	GOA
involved in mitotic G1 DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	21329877	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	22354037	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	21329877	GOA
involved in positive regulation of macroautophagy	IMP IMP: 通过突变表型推断	22354037	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WAC 蛋白结构

0
100
200
300
400
500
600
647 a.a.

蛋白主名

其他名称

WW domain-containing adapter protein with coiled-coil

WAC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WAC	Q9BTA9	KLC3	Homo sapiens	Q6P597	Validated Y2H	25416956
种属内	WAC	Q9BTA9	NFE2L2	Homo sapiens	Q16236	Y2H Array	25416956
种属内	WAC	Q9BTA9	NFE2L2	Homo sapiens	Q16236	Y2H Prey Pooling	25416956
种属内	WAC	Q9BTA9	SYTL5	Homo sapiens	Q8TDW5	Y2H Array	25416956
种属内	WAC	Q9BTA9	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
种属内	WAC	Q9BTA9	HTT	Homo sapiens	P42858	Y2H	17500595
种属内	WAC	Q9BTA9	KRT15	Homo sapiens	P19012	Y2H Array	25416956
种属内	WAC	Q9BTA9	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	25416956
种属内	WAC	Q9BTA9	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	25416956
种属内	WAC	Q9BTA9	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
种属内	WAC	Q9BTA9	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
种属内	WAC	Q9BTA9	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
种属内	WAC	Q9BTA9	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Prey Pooling	25416956
种属内	WAC	Q9BTA9	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	25416956
种属内	WAC	Q9BTA9	AKAP9	Homo sapiens	Q99996-2	Y2H Prey Pooling	25416956
种属内	WAC	Q9BTA9	AKAP9	Homo sapiens	Q99996-2	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Desanto-Shinawi Syndrome

Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation	Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To 10p11.21p12.31 Microdeletion
Wac-Related Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome	DESSH
Developmental Delay, Behavioral Abnormalities, Facial Dysmorphism, And Ocular Abnormalities	Chromosome 10p12-P11 Deletion Syndrome
10p12p11 Microdeletion Syndrome	Del(10)(P11.21p12.31)
Deletion 10p11.21p12.31	Monosomy 10p11.21p12.31

Branchial Cleft Anomalies

Second Branchial Cleft Cyst	Second Branchial Cleft Anomaly
Second Branchial Cleft Fistula

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Hypotonia

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Constipation

Weyers Acrofacial Dysostosis

Curry-Hall Syndrome	Weyers Acrodental Dysostosis
WAD	Acrodental Dysostosis Of Weyers
Acrofacial Dysostosis, Weyers Type	Acrofacial Dysostosis Of Weyers
Curry Hall Syndrome

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15737	WAC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	WAC	VGNC	VGNC:66997
Mus musculus	WAC	MGD	MGI:2387357
Rattus norvegicus	WAC	RGD	RGD:1562407
Macaca mulatta	WAC	VGNC	VGNC:79072
Bos taurus	WAC	VGNC	VGNC:36861

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WAC - WW domain containing adaptor with coiled-coil Gene

关于 WAC

功能概要

WAC 基因产物(3)

WAC 蛋白结构

WAC 蛋白互作信息

关联疾病

直系同源

热门区域

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WAC - WW domain containing adaptor with coiled-coil Gene

关于 WAC

功能概要

WAC 基因产物(3)

WAC 蛋白结构

WAC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z