2. Gene
  3. GSTZ1 - glutathione S-transferase zeta 1 Gene

GSTZ1 - glutathione S-transferase zeta 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷胱甘肽 S-转移酶 zeta 1

种属: Homo sapiens

同用名: MAI; MAAI; MAAID; GSTZ1-1

基因 ID: 2954 | 基因类型: protein coding

关于 GSTZ1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,321,036-77,331,597 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues, 14 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 23.8), testis (RPKM 10.9) and 24 other tissues.

功能概要

该基因是谷胱甘肽 S-转移酶 (GST) 超家族的成员，该家族编码的多功能酶通过与谷胱甘肽结合，在亲电分子 (包括致癌物、诱变剂和几种治疗药物) 的解毒中很重要。该酶催化马来酰乙酰乙酸转化为富马酰乙酰乙酸，这是苯丙氨酸/酪氨酸降解途径中的步骤之一。小鼠中类似基因的缺陷会导致氧化应激。该基因的几个转录变体编码多种蛋白质亚型。[RefSeq 提供，2015 年 7 月]

This gene is a member of the Glutathione S-transferase (GSTs) super-family which encodes multifunctional Enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This Enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]

GSTZ1 基因产物(4)

mRNA Protein Name
NM_001312660.2 NP_001299589.1 maleylacetoacetate isomerase isoform 3
NM_001363703.2 NP_001350632.1 maleylacetoacetate isomerase isoform 4
NM_145870.3 NP_665877.1 maleylacetoacetate isomerase isoform 1
NM_145871.3 NP_665878.2 maleylacetoacetate isomerase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione transferase activity IDA
IDA: 通过直接分析推断
10739172 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables maleylacetoacetate isomerase activity IDA
IDA: 通过直接分析推断
10739172 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
10739172 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular detoxification IDA
IDA: 通过直接分析推断
20884751 GOA
involved in glutathione metabolic process IDA
IDA: 通过直接分析推断
10739172 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
20884751 GOA
is active in mitochondrion IDA
IDA: 通过直接分析推断
20884751 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSTZ1 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (8 - 86)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (130 - 193)

  • 0
  • 100
  • 200
  • 216 a.a.
蛋白主名 其他名称

maleylacetoacetate isomerase

S-(hydroxyalkyl)glutathione lyase

GSTZ1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GSTZ1 O43708 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
种属内
GSTZ1 O43708 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
种属内
GSTZ1 O43708 CLVS2 Homo sapiens Q5SYC1
Validated Y2H
32296183
种属内
GSTZ1 O43708 CLVS2 Homo sapiens Q5SYC1
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 CLVS2 Homo sapiens Q5SYC1
Y2H Array
32296183
种属内
GSTZ1 O43708 TCP11 Homo sapiens Q8WWU5-7
Validated Y2H
32296183
种属内
GSTZ1 O43708 QARS1 Homo sapiens P47897
Validated Y2H
32296183
种属内
GSTZ1 O43708 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
种属内
GSTZ1 O43708 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
种属内
GSTZ1 O43708 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
种属内
GSTZ1 O43708 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
种属内
GSTZ1 O43708 GSTZ1 Homo sapiens O43708
Y2H Array
32296183
种属内
GSTZ1 O43708 GSTZ1 Homo sapiens O43708
Y2H Array
25416956
种属内
GSTZ1 O43708 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属内
GSTZ1 O43708 GSTZ1 Homo sapiens O43708
Y2H Pooling
16189514
种属内
GSTZ1 O43708 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
种属内
GSTZ1 O43708 GSTZ1 Homo sapiens O43708
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
种属内
GSTZ1 O43708 GSTZ1 Homo sapiens O43708
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GSTZ1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70206A Maleylacetoacetate isomerase/GSTZ1 Protein, Human (N-His) NP_665877.1 (Q2-A216) ≥95%

关联疾病

疾病名称 别名
Maleylacetoacetate Isomerase Deficiency

MAAID

Maai Deficiency

Hypersuccinylacetonemia, Mild

Mhsa

Benign Hypersuccinylacetonemia

Bhsa
Tyrosinemia, Type I

Tyrosinemia Type I

Hepatorenal Tyrosinemia

Fumarylacetoacetase Deficiency

Fah Deficiency

TYRSN1

Fumarylacetoacetate Hydrolase Deficiency

Tyrosinemia Type 1

Tyrosinemia 1

Fumarylacetoacetase
Tyrosinemia

Hypertyrosinemia

Tyrosinemias

Hereditary Tyrosinemia

Hypertyrosinaemia

Tyrosinaemia

Hereditary Hypertyrosinemia
Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency

4-Hppd Deficiency

4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency

HWKS

HAWK
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Alkaptonuria

Homogentisic Acid Oxidase Deficiency

Alcaptonuria

AKU

Deficiency Of Homogentisicase

Homogentisate 1,2-Dioxygenase Deficiency

Alkaptonuric Ochronosis

Homogentisic Acidura

Ochronosis, Hereditary

Hereditary Ochronosis

Ochronosis

Homogentisicaciduria

Deficiency Of Homogentisate Oxygenase
Tyrosinemia, Type Iii

Tyrosinemia Type Iii

4-Hydroxyphenylpyruvate Dioxygenase Deficiency

TYRSN3

4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Type 3

4-Alpha Hydroxyphenylpyruvate Dioxygenase Deficiency

4-Alpha Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvate Dioxygenase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To Hpd Deficiency

Tyrosinemia 3
Tyrosinemia, Type Ii

Tyrosinemia Type Ii

Oculocutaneous Tyrosinemia

Richner-Hanhart Syndrome

Tyrosine Aminotransferase Deficiency

Tat Deficiency

Tyrosine Transaminase Deficiency

Keratosis Palmoplantaris With Corneal Dystrophy

TYRSN2

Oregon Type Tyrosinemia

Tyrosinemia Type 2

Tyrosinosis Oculocutaneous Type

Tyrosinosis, Oculocutaneous Type

Richner Hanhart Syndrome

Keratosis Palmoplantaris-Corneal Dystrophy Syndrome

Tyrosinemia Due To Tat Deficiency

Tyrosinemia Due To Tyrosine Aminotransferase Deficiency

Tyrosinemia 2

Tyrosinemia Oregon Type

Tyrosine Transaminase Deficiency Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05889 GSTZ1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GSTZ1 VGNC VGNC:67491
Mus musculus GSTZ1 MGD MGI:1341859
Macaca mulatta GSTZ1 VGNC VGNC:73304
Rattus norvegicus GSTZ1 RGD RGD:1589363
Bos taurus GSTZ1 VGNC VGNC:29688
Canis familiaris GSTZ1 VGNC VGNC:41537
Others GSTZ1 NCBI
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